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eotaxin-1 and eotaxin-2 252 epithelial cell adhesion molecule (EpCAM)
IL-5
Th2 Lymphocyte
eotaxin-1 and eotaxin-2
CC-chemokines that exert specific action on eosinophils.
Referred to as CXCL11 and CXCL24, respectively.
eph receptors and ephrins
The eph receptors constitute the largest known subfamily
of receptor tyrosine kinases. The ligands are called ephrins.
The ephrin–eph interactions are important in development,
especially in cell–cell interactions involved in nervous system
patterning (axon guidance) and possibly in cancer.
ephrin/eph
Endothelial cells destined to become arteries express
ephrin-B2 while the cognate receptor, eph B4, is expressed
on endothelial cells destined to become veins. The ephrin/
eph family of cell-surface proteins is important in the cell–
cell recognition and signaling of nervous system patterning.
Their specific locations on venous versus arterial endothelial
cells suggests that the formation of a vascular system
may be appreciably more complicated than predicted.
epibody
An anti-idiotypic antibody reactive with an idiotype of a
monoclonal, human anti-IgG autoantibody as well as with
IL-4
Eosinophil
VCAM
CKR-3
Eotaxin
The interaction of cytokines and adhesion molecules in attraction of eosinophils. Recruitment of eosinophils has two separate stages. An increase in circulating
eosinophils results from IL5 stimulation of bone marrow growth, differentiation, and release of eosinophils. Attraction of eosinophils to specific
tissues presumably involves their adhesion to the endothelium, possible stimulated by IL4-induced expression of VCAM1, followed by chemoattraction by
eotaxin and by other nonspecific chemoattractants and activators.
Ab 1 Fc
Epibody.
FcAb 2 ε
FcAg
(Human IgG)
the human IgG Fc region. These antibodies identify an
antigenic determinant associated with the Ser–Ser–Ser
sequence. The ability of an epibody to identify an epitope
shared by a rheumatoid factor idiotope and an Fcγ epitope
demonstrates that this variety of anti-idiotypic antibody
may function as a rheumatoid factor.
epidemic
An infectious disease outbreak that affects numerous members
of a population.
epidermal growth factor (EGF)
A trisulfated polypeptide consisting of 53 residues. It is a
member of the tyrosine kinase family and is related to the
erb oncogene. EGF has multiple functions, including stimulation
of the mitogenic response and facilitation of wound
healing, among others. It is present in the saliva of rodents.
epidermal growth factor receptor (EGFR)
A 400-amino-acid protein found in T cell carcinomas,
neurons, cornea, fibroblasts, T lymphocytes, liver, vascular
endothelium, and placenta. EGFR measurement is used to
judge the aggressiveness of such neoplasias as breast cancer.
epidermis
The upper layers of skin that contain principally keratinocytes
in addition to skin-associated lymphoid tissue (SALT)
constituents but no blood vessels.
epidermolysis bullosa acquisita (EBA)
An uncommon blistering disease characterized by recurrent
bullae that heal with scarring. The lesions occur in areas of
trauma, especially on the dorsal surfaces of the hands. The
split is subepidermal and occurs below the lamina densa of
the BMZ. Patients have immunoglobulin G (IgG) autoantibodies
that react with various epitopes within the NC1
domain of type VII collagen, the principal constituent of
the dermal anchoring fibrils. Dominant epitopes are present
in fibronectin-like repeats within the molecule. The disease
has an association with HLA-DR2.
epigenetic factors
Factors such as extrachromosomal DNA and environmental
stressors that influence the expression of a chromosomally
integrated gene.
epithelial cell adhesion molecule (EpCAM)
Considered a pan-carcinoma antigen, EpCAM is highly
expressed on a variety of adenocarcinomas of different