Untitled - D Ank Unlimited

acute graft rejection 11 acute graft rejection
Gastrointestinal graft-vs.-host disease in which there is a diffuse process
that usually involves the ileum and cecum most severely, resulting in
secretory diarrhea. Grossly, diffuse erythema, granularity, and loss of
folds are observed; when severe, undermining and sloughing of the entire
mucosa lead to fibrinopurulent clots of necrotic material. Frank obstruction
is sometimes found in patients with intractable graft-vs.-host disease.
Stenotic and fibrotic segments alternating with more normal appearing
dilated segments of gut in graft-vs.-host disease.
acute graft rejection
Recipient host rejection of a transplanted solid organ or
tissue transplant within days or weeks following transplantation.
The mechanism may be acute cellular rejection or
antibody-mediated acute humoral rejection.
Sloughing of mucosal lining of the gut in graft-vs.-host disease.
Histologically, graft-vs.-host disease in the gut begins as a patchy destructive
enteritis localized to the lower third of the crypts of Lieberkühn.
The earliest lesions are characterized by individual enterocyte necrosis
with karyorrhectic nuclear debris, the so-called exploding crypt, which progresses
to a completely destroyed crypt, as shown in the upper left corner.
Hepatic graft-vs.-host disease is characterized by a cholestatic hepatitis
with characteristic injury and destruction of small bile ducts that resemble
changes seen in rejection. This section of early acute disease shows mile
portal infiltrates with striking exocytosis into bile ducts associated with
individual cell necrosis and focal destruction of the bile ducts.
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