Untitled - D Ank Unlimited

e allotype
Rabbit immunoglobulin G (IgG) heavy chain or e allotypes
are determined by an amino acid substitution at position
309 in C H2. The e14 allotype heavy chains possess threonine
at position 309, whereas e15 allotype heavy chains
possess alanine at that location. They are determined by
alleles at the de locus that encodes rabbit gamma chain
constant regions.
E antigen
A hepatitis B virus antigen present in the sera of chronic
active hepatitis patients.
E-cadherin
E-cadherin and its associated cytoplasmic proteins α-, β-,
and γ-catenin play an important role in epithelial cell–cell
adhesion and in the maintenance of tissue architecture.
Downregulation or mutation of the E-cadherin/catenin
genes can disrupt intercellular adhesion, which may lead to
cellular transformation and tumor progression.
Erythrocyte
LFA-3
CD2
T cell
E rosette.
E rosette
Human T lymphocyte encircled by rings of sheep red blood
cells. It was used previously as a method to enumerate
T lymphocytes. Refer also to E rosette-forming cell.
e
E rosette-forming cell
The formation of a complex of sheep red cells encircling
a T lymphocyte to form a rosette. This was one of the
first methods for enumerating human T cells, as the sheep
red cells did not form spontaneous rosettes with human B
lymphocytes. This is now known to be due to the presence
of the CD2 marker that is a cell adhesion (LFA-2) molecule
on T cells. CD2 + T cells are now enumerated by the use of
monoclonal antibodies and flow cytometry.
E-selectin (endothelial leukocyte
adhesion molecule 1 [ELAM-1])
A molecule found on activated endothelial cells that recognizes
sialylated Lewis X and related glycans. Its expression
is associated with acute cytokine-mediated inflammation.
Also called CD62E.
E2A
A transcription factor, critical for B lymphocyte development
that is necessary for recombinase-activating gene
(RAG) expression and expression of the λ 5 pre-B cell
component in B cell development. Also called CD62E.
E5
Murine monoclonal immunoglobulin M (IgM) antibody to
endotoxin that has proven safe and capable of diminishing
mortality and helping to reverse organ failure in patients
with Gram-negative sepsis who are not in shock during therapy.
E5 may recognize and combine with lipid A epitope.
E32
A protein formed early in development of B lymphocytes
that has a role in immunoglobulin heavy chain transcription.
EA
An erythrocyte (E) coated with a specific antibody (A) that
constitutes a technique to measure the activities of Fcγ receptors.
Sheep red blood cells with subagglutinating quantities
of immunoglobulin G (IgG) antibodies are placed in contact
with cells at room temperature. IgG Fc receptor-bearing cells
will combine with the EA, resulting in rosette formation.
EAC
Abbreviation for erythrocyte (E), antibody (A), and
complement (C), as designated in studies involving the
complement cascade. Historically, sheep red blood cells
have been combined with antibody specific for them,
and lysis is induced only after the addition of complement.
This interaction of the three reagents has served as
a useful mechanism to study the reaction sequence of the
multiple-component complement system, which is often
written as EAC1423, etc. EAC may also be employed to
reveal the presence of complement receptors 1 through 4.
The combination of IgM-coated sheep red blood cells with
sublytic quantities of complement to produce EAC provides
a mechanism whereby rosettes are formed by cells bearing
complement receptors once the EAC is layered onto test
cells at room temperature. EAC rosette erythrocytes such as
sheep red blood cells, coated or synthesized with antibody
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E