Untitled - D Ank Unlimited

designer lymphocytes 224 desotope
T-cell receptor
Processed antigen
MHC class II
Antigen-presenting
cell
T cell
antibodies produced by linking mouse gene segments that
encode the variable region of immunoglobulin with those
that encode the constant region of a human immunoglobulin.
This technique provides the antigen specificity obtained
Enh
V H
D JH V H
1 2 3
Cµ
4
Enh
Paratope
Restitope
Epitope
Histotope
Desetope
Agretope
Interaction of major histocompatibility complex (MHC) class II, processed
peptide, and T cell receptor molecules during antigen presentation.
2
T cell receptor
Processed
antigen
Paratope
Epitope
Agretope
Desetope
T cell
Resitope
Histotope
MHC class II
molecule
Co-stimulatory
signal
1
Antigen
presenting cell
Binding of the MHC complex
Costimulator for activation of T cells.
CD4
S
1 2
M
3
Cµ
from the mouse antibody, while substituting the less immunogenic
Fc region of the molecule from a human source. It
greatly diminishes the likelihood of an immune response in
humans receiving the hybrid immunoglobulin molecules, as
most of the mouse immunoglobulin Fc region epitopes have
been eliminated through the human Fc substitution.
designer lymphocytes
Lymphocytes into which genes have been introduced to
increase the ability of cells to lyse tumor cells. Tumorinfiltrating
lymphocytes transfected with these types of genes
have been used in experimental adoptive immunotherapy.
desmin
A 55-kDa intermediate filament molecule found in
mesenchymal cells that include both smooth and skeletal
muscle, endothelial cells of the vessels, and probably
myofibroblasts. In surgical pathologic diagnosis, monoclonal
antibodies against desmin are useful to identify muscle
tumors.
desmin (D33) mouse antibody
An antibody that detects a protein that is expressed by
cells of normal smooth, skeletal and cardiac muscle. Light
microscopy has suggested that desmin is primarily located
at or near the peripheries of Z lines in striated muscle
fibrils. In smooth muscle, desmin interconnects cytoplasmic
dense bodies with membrane-bound dense plaques.
Desmin antibody reacts with leiomyomas, rhabdomyomas,
and perivascular cells of glomus tumors of the skin (if they
are of myogenic nature). This antibody is basically used to
demonstrate the myogenic components of carcinosarcomas
and malignant mixed mesodermal tumors.
desmoglein
A protein constituent of desmosomes. A transmembrane
glycoprotein that is one of the three components in a complex
of epidermal polypeptides formed from the immunoprecipitate
of pemphigus foliaceous autoantibodies.
desmosomes
Specialized junctions that connect keratinocytes to one
another and guarantee that each keratinocyte layer divides
and migrates upward as a unit.
desotope
A term derived from determinant selection. It describes the
region of class II histocompatibility molecules that reacts
4 S M
Designer antibody.
D
DJ H rearrangement
V to DJ H rearrangement
J H