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dermatomyositis 223 designer antibody
of the pharmacological mediators of immediate hypersensitivity
through physical stimulation. It is an example of an
anaphylactoid reaction.
Dermatomyositis.
Dermatomyositis.
dermatomyositis
A connective tissue or collagen disease characterized by skin
rash and muscle inflammation. It is a type of polymyositis
presenting with a purple-tinged skin rash that is prominent on
the superior eyelids, extensor joint surfaces, and base of the
neck. Weakness, muscle pain, edema, and calcium deposits
in the subcutaneous tissue are especially prominent late in the
disease. Blood vessels reveal lymphocyte cuffing, and autoantibodies
against tRNA synthetases appear in the serum.
dermatopathic lymphadenitis
Benign lymph node hyperplasia that follows skin inflammation
or infection.
Dermatophagoides
The house mite genus. Constituents of house mites represent
the main allergens in house dust.
Dermatomyositis. Anti-IgG staining.
Dermatophagoides pteronyssinus
A house dust mite whose antigens may be responsible for
house dust allergy in atopic individuals. It is a common
cause of asthma.
dermatophytid reaction
Refer to id reaction.
dermis
The skin layer below the epidermis and basement membrane
composed of blood vessels, lymphatic vessels, nerve
fibers, scattered fibroblasts, macrophages, mast dells, dendritic
cells and αβ T cells. The papillary dermis is beneath
the basement membrane and the reticular dermis is beneath
the papillary dermis. Both papillary and reticular dermis
are comprised of collagen and elastin fiber networks in a
hyaluronic acid matrix.
Antibody Levels
3 6 12 24
Desensitization.
IgG antibody
IgE antibody
desensitization
A method of treatment used by allergists to diminish
the effects of immunoglobulin E (IgE)-mediated type I
hypersensitivity. The mechanism is believed to alter the
balance between CD4 + T h1 and T h2 cells, thereby switching
the antibodies synthesized from IgE to IgG. The allergen
to which an individual has been sensitized is repeatedly
injected in a form that favors the generation of IgG (blocking)
antibodies rather than IgE antibodies that mediate type
I hypersensitivity in humans. This method has been used
for many years to diminish the symptoms of atopy, such as
asthma and allergic rhinitis, and prevent anaphylaxis produced
by bee venom. IgG antibodies are believed to prevent
antigen interaction with IgE antibodies anchored to mast
cell surfaces by intercepting the antigen molecules before
they reach the cell-bound IgE. Thus, a type I hypersensitivity
reaction of the anaphylactic type is prevented.
desetope
A term that originates from determinant selection. It
describes the regions of class II histocompatibility molecules
that react with antigen during antigen presentation.
Allelic variation permits these contact residues to vary,
which is one of the factors in histocompatibility molecule
selection of a particular epitope being presented.
designer antibody
A genetically engineered immunoglobulin needed for a specific
purpose. The term has been used to refer to chimeric
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