Untitled - D Ank Unlimited

dendritic epidermal cell 221 dense deposit disease
by mechanisms involved in migration and function. DCs are
being considered as adjuvants in immunization protocols
for antiviral or antitumor immunity. Immature DCs are
defined by cell surface markers that represent functional
capacity. They express the chemokine receptors CCR-1,
CCR-2, CCR-5, CCR-6, (only CD34 + HPC-derived DCs),
and CXCR-1, commonly thought to allow DCs to migrate in
response to inflammatory chemokines expressed by inflamed
tissues. Immature DCs are phagocytic and have high levels
of macropinocytosis, allowing them to efficiently process
and present antigen on class I molecules. Expression of Fcγ
(CD64) and the mannose receptors allows efficient capture
of immunoglobulin G (IgG) immune complexes and antigens
that expose mannose or fucose residues. The expression
of E-cadherin allows DCs to interact with tissue cells and
remain in the tissues until activated. Following antigen processing,
DCs are remodeled. Fc and mannose receptors are
downregulated and the acidic interacellular compartments
disappear, resulting in a loss of endocytic activity. During
this maturation process, the level of MHC class II molecules
and costimulatory molecules are unregulated, and chemokine
receptor expression changes. Maturing DCs home to T cell
areas of secondary lymph nodes, where they present antigen
to naïve T cells. In vitro culture of DCs with CD40-L, LPS,
and TNF-α generates mature DCs. These cells are very good
stimulators of allogeneic T cell proliferation. The DC–T cell
interaction is thought to be a two-way interaction. Evidence
suggests that T cells interact with DC through CD40 ligation
to enhance DC viability and their T cell stimulatory ability.
Addition of CD40-L induces DCs to produce interleukin-12
(IL12), which is known to support T H1 responses.
Lipopolysaccharide stimulation generates a weaker in vitro
immune response than the CD40-L-stimulated DCs.
dendritic epidermal cell
Mouse epidermal cells that are Thy-1 positive and major
histocompatibility complex (MHC) class II molecule-negative
and possess γδ T cell receptor associated with CD3.
This cell is believed to be a variety of bone marrow-derived
T lymphocyte separate from Langerhans’ cells in the skin.
dendritic epidermal T cells (deTC)
Specialized epidermal γδ T cells present in mice and
selected other species but absent from human skin. These
cells share a common γδ T cell receptor but their function is
unknown.
dengue
An infection produced by the group B flavivirus arbovirus
transmitted by the Stegomyia Aedes aegypti mosquito.
Dengue fever, found in the tropical regions of Africa and
America, may either be benign or produce malignant
dengue hemorrhagic shock syndrome, in which patients
experience severe bone pain (break bone fever). They have
myalgia, biphasic fever, headache, lymphadenopathy, and
a morbilliform maculopapular rash on the trunk. They
also manifest thrombocytopenia and lymphocytopenia.
de novo pathway of nucleic acid synthesis
A biosynthetic mechanism whereby new nucleotides are constructed
from amino acids. Aminopterin blocks the process.
dense deposit disease
Type II membranoproliferative glomerulonephritis is
characterized by the deposition of electron-dense material,
often containing C3, in the peripheral capillary basement
membrane of the glomerulus. C3 is decreased in the serum
Dense deposit disease.
Dense deposit disease.
Dense deposit disease.
Dense
deposits
in glomerular
capillary
basement
membrane
D