Untitled - D Ank Unlimited

d-amino acid polymers
Synthetic peptides (and polypeptides) that are antigenic.
They are found very infrequently in living organisms.
D exon
A DNA sequence that encodes a portion of the third hypervariable
region of the immunoglobulin heavy chain. It is
situated on the 5′ sides of J exons. An intron lies between
them. During lymphocyte differentiation, V–D–J sequences
that encode the complete variable region of the heavy chain
are produced.
D gene
A small segment of immunoglobulin heavy chain and T cell
receptor DNA that encodes the third hypervariable regions
of most receptors.
D gene region
Diversity region of the genome that encodes heavy chain
sequences in the immunoglobulin heavy chain hypervariable
region.
D gene segment
The DNA region that codes for the D (or diversity) portion
of an immunoglobulin heavy chain or a T lymphocyte
receptor β or δ chain. It is the segment that encodes the
third hypervariable region situated between the chain
regions that the V and J gene segments encode. This part of
the heavy chain variable region is frequently significant in
determining antibody specificity.
D region
A segment of an immunoglobulin heavy-chain variable
region or the β or δ chain of the T lymphocyte receptor
coded for by a D gene segment. A few residues constitute
the D region in the third hypervariable region in most heavy
chains of immunoglobulins. The D (or diversity) region
governs antibody specificity and probably T cell receptor
specificity, as well.
D3TX mice
More than 95% of female D3TX mice develop autoimmune
oophoritis, whereas only 30% of D3TX male mice
develop autoimmune orchitis. Following vasectomy, orchitis
in D3TX mice increases to over 90%. Because vasectomy
is associated with leakage of sperm antigens, the different
incidence of orchitis and oophoritis in D3TX mice
µ
Chain
gene
Leader
peptide
V
DJ
D
is believed to indicate a difference in the sequestration
between testicular and ovarian antigens.
daclizumab
An immunosuppressive agent that acts as an IL2 receptor
antagonist by binding with high affinity to the Tac subunit
of the high affinity IL2 receptor complex and blocks IL2
binding. It is highly specific for Tac, which is expressed on
activated but not resting lymphocytes. Daclizumab injection
inhibits IL2-mediated activation of lymphocytes, which is
important in cell-mediated immune responses in allograft
rejection. Daclizumab in the circulation impairs the
response of the immune system to antigenic challenge.
DAF
Refer to decay-accelerating factor.
Dale, Henry Hallett (1875–1968)
British investigator who made a wide range of scientific
contributions, including work on the chemistry of nerve
impulse transmissions, the discovery of histamine, and the
development of the Schultz–Dale test for anaphylaxis. He
received a Nobel Prize in 1935.
Dalen–Fuchs nodule
A hemispherical granulomatous nodule composed of
epithelioid cells and retinal epithelial cells in the choroids
Structure of Heavy Chain Gene From IgM-Producing Cell
C µ 1
C µ 2
C µ 3
D exon and V segment.
C µ 4
Tail sequence
Henry Hallett Dale.
Tm
215
D