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cowpox 199 C-reactive protein (CRP)
cowpox
A bovine virus disease that induces vesicular lesions on
the teats. It is of great historical significance in immunology
because Edward Jenner observed that milkmaids who
had cowpox lesions on their hands failed to develop smallpox.
He used this principle in vaccinating humans with the
cowpox preparation to produce harmless vesicular lesions
at the site of inoculation (vaccination). This stimulated
protective immunity against smallpox (variola) because of
shared antigens between the vaccinia virus and the variola
virus.
coxsackie
A picornavirus family from Enteroviridiae. Coxsackie A
viruses have 23 virotypes and coxsackie B viruses have 6
types. Clinical conditions produced by coxsackie viruses
include herpangina, epidemic pleurodynia, aseptic meningitis,
summer grippe, and acute nonspecific pericarditis
and myocarditis.
James Gillray’s cartoon of the cowpox.
C-reactive protein (CRP).
CpG nucleotides
Bacterial DNA unmethylated cytidine–guanine sequences
that facilitate immune responses acting as an adjuvant.
They are believed to enhance DNA vaccine efficacy.
CR, CR1, CR2, CR3, CR4
Abbreviations for complement receptors.
CR1
Refer to complement receptor 1.
CR2
Refer to complement receptor 2.
CR2, type II complement receptor
A coreceptor on B lymphocytes that binds to antigens
coated with complement at the same time that membrane
immunoglobulin binds an epitope of the antigen.
CR3 deficiency syndrome
Refer to leukocyte adhesion deficiency.
C-reactive protein (CRP)
An acute phase 115-kDA protein. One of the pentraxin
proteins in serum. It is comprised of five 206-amino acid
C