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Cogan’s syndrome 182 collagen
Cogan’s syndrome
Corneal inflammation (interstitial keratitis) and inflammation
of the ear, leading to nausea, vomiting, vertigo,
and ringing in the ears. This may be associated with
connective tissue disease or may occur following an
infection.
cognate antigen
An epitope recognized to be identified by a specific lymphocyte
antigen receptor because it was used initially to
activate that lymphocyte.
cognate interaction
Processed antigen on a B cell surface interacting with a T
cell receptor for antigen resulting in B cell differentiation
into an antibody-producing cell.
cognate recognition
Refer to cognate interaction.
Cohn fraction II
γ-Globulin isolated by ethanol fractionation of serum by the
method of Cohn.
Cohnheim, Julius (1839–1884)
German experimental pathologist who was the first proponent
of inflammation as a vascular phenomenon. (Refer to
Lectures on General Pathology, 1889.)
coisogenic
Refer to congenic strains.
coisogenic strain
Inbred mouse strain that has an identical genotype except
for a difference at one genetic locus. A point mutation in
an inbred strain provides the opportunity to develop a coisogenic
strain by inbreeding the mouse in which the mutation
occurred. The line carrying the mutation is coisogenic
with the line not expressing the mutation. Considering the
problems associated with developing coisogenic lines, congenic
mouse strains were developed as an alternative. Refer
to congenic strains.
cold agglutinin
An antibody that agglutinates particulate antigen, such
as bacteria or red cells, optimally at temperatures less
than 37°C. In clinical medicine, the term usually refers to
antibodies against red blood cell antigens as in the cold
agglutinin syndrome.
cold agglutinin syndrome
An immune condition in which immunoglobulin M (IgM)
autoantibodies agglutinate erythrocytes most effectively at
4°C. Normal individuals may have cold agglutinins in low
titer (