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chronic thyroiditis 172 cimetidine
and has been referred to as graft arteriosclerosis. Induced
by antibodies against graft HLA class I alloantigens.
chronic thyroiditis
An autoimmune disease that leads to progressive destruction
of the thyroid gland as in Hashimoto’s thyroiditis. An
inflammatory disease of the thyroid found most frequently
in middle-age to older women. There is extensive infiltration
of the thyroid by lymphocytes that completely replace
the normal glandular structure of the organ. The numerous
plasma cells, macrophages, and germinal centers give
the appearance of a node structure within the thyroid
gland. Both B cells and CD4 + T lymphocytes comprise the
principal infiltrating lymphocytes. Thyroid function is first
increased as inflammatory reaction injures thyroid follicles,
causing them to release thyroid hormones. However, this
increase is soon replaced by hypothyroidism in the later
stages of Hashimoto’s thyroiditis. Patients with this disease
have enlarged thyroid glands. There are circulating autoantibodies
against thyroglobulin, and thyroid microsomal
antigens may be present (thyroid peroxidase). Cellular sensitization
to thyroid antigens may also be detected. Thyroid
hormone replacement therapy is given for the hypothyroidism
that develops.
chronic xenograft rejection
Xenograft failure that occurs within weeks following transplantation
as a consequence of cytotoxic T lymphocytes,
NK cells reacting against donor endothelium. Also called
cellular xenograft rejection.
chrysotherapy
Refer to gold therapy.
Churg–Strauss syndrome (allergic granulomatosis)
A combination of asthma associated with necrotizing
vasculitis, eosinophilic tissue infiltrates, and extravascular
granulomas.
CIA
Abbreviation for collagen-induced arthritis.
CIC
Abbreviation for circulating immune complexes.
cicatricial ocular pemphigoid
A rare blistering disorder of the conjunctival mucous
membrane that may lead to scarring and result in blindness
if untreated with corticosteroids. Histopathologically, the
subepithelial unilocular bulla is accompanied by a mild
inflammatory reaction. Direct immunofluorescence reveals
a diffuse, linear deposition of immunoglobulins and components,
mainly IgG and C3 at the epithelial–subepithelial
junction.
CID
Abbreviation for (1) cytomegalic (CMV) inclusion disease
and (2) combined immunodeficiency.
CIE
Abbreviation for counterimmunoelectrophoresis or
crossed immunoelectrophoresis.
CIIV
Abbreviation for class II vesicle. Refer to MIICs.
cilia
Hair-like projections on respiratory and gastrointestinal tract
epithelial cells. Cilia propel microorganisms out of the tract.
ciliary neurotrophic factor (CNTF)
A protein hormone related to the IL6 family. It performs
several functions in the nervous system which are similar to
those of leukemia inhibitory factor.
Cicatricial ocular pemphigoid stained with anti-IgG antibody.
Cicatricial ocular pemphigoid stained with anti-IgG antibody.
cimetidine
An H 2-receptor antagonist capable of more than 90% reduction
in food-stimulated and nocturnal secretion of gastric
acid after a single dose. A well known treatment for peptic
ulcers. This histamine H 2-receptor antagonist is of interest