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CDR 158 cell adhesion molecules (CAMs)
CDR
Abbreviation for complementarity-determining regions.
CEA
Abbreviation for carcinoembryonic antigen.
cecropin
An antibacterial protein derived from immunized cecropia
moth pupae and also found in butterflies. Cecropin is a
basic protein that induces prompt lysis of selected Gramnegative
and Gram-positive bacteria.
celiac disease
An inflammatory immunological disease of the intestinal
mucosa attributable to an immune response against gluten
proteins found in selected cereals, including wheat. Refer to
gluten-sensitive enteropathy.
celiac sprue (gluten-sensitive enteropathy)
Gluten-sensitive enteropathy resulting from hypersensitivity
to cereal grain storage proteins, including gluten or its
product gliadin, present in oats, wheat, and barley. It is characterized
by villous atrophy and malabsorption in the small
intestine. It occurs mostly in Caucasians and occasionally in
African-Americans, but not in Asians. Individual patients
may have the disease limited to the intestines or associated
with dermatitis herpetiformis, a vesicular eruption of the
skin. The mucosa of the small intestine shows the greatest
reactivity in areas in contact with gluten-containing food.
Antigliadin antibodies are formed, and lymphocytes and
plasma cells appear in the lamina propria in association with
villous atrophy. Gluten-sensitive enteropathy is associated
with HLA-DR3, -DR7, and -DQ2, as well as with HLA-B8.
Diagnosis is made by showing villous atrophy in a biopsy of
the small intestine. Administering a gluten-free diet leads
to resolution of the disease. Antigliadin antibodies are of
the immunoglobulin A (IgA) class. Both T and B cell limbs
Cellular Adhesion Molecules (CAMS).
of the immune response participate in the pathogenesis of
this disease. Patients may also develop IgA or IgG reticulin
antibodies. An α gliadin amino acid sequence shares homology
with adenovirus 12Elb early protein. Patients with celiac
disease develop immune reactivity for both gliadin and this
viral peptide sequence. The disease occurs more frequently
in individuals exposed earlier to adenovirus 12. Patients
develop weight loss, diarrhea, anemia, petechiae, edema, and
dermatitis herpetiformis, among other signs and symptoms.
Lymphomas such as immunoblastic lymphoma may develop
in 10 to 15% of untreated patients.
VCAM-1 bound to an endothelial cell.
cell adhesion molecules (CAMs)
Molecules on cell surfaces that facilitate the binding of cells
to each other in tissues and in cell-to-cell interactions. They
also facilitate cell-to-matrix adhesion and extravasation.