Untitled - D Ank Unlimited

CD72 150 CD92
homodimeric glycoprotein present on activated T and
B cells, on macrophages, and in proliferating cells. The
main function of this receptor is the binding of transferrin.
By internalization of the receptor and its ligand
within cells, iron is delivered for cellular metabolism.
Also called T9.
CD72
An antigen (molecular weight of 43 and 39 kDa) that is a
heterodimeric glycoprotein. The CD72 antigen is a pan-B
cell marker that occurs like the CD19 antigen at the earliest
stages of B cell differentiation. The antigen is expressed
from the pro-B cell stage until the plasma cell stage. It is
the ligand for CD5.
CD73
A 69-kDa molecule that is an ecto-5′ nucleotidase found
on B and T cell subsets, dendritic reticulium cells, epithelial
cells, and endothelial cells. It is expressed weakly on
pre-B cells until the final plasma cell stage, where it is lost.
CD73 dephosphorylates nucleotides to permit uptake of
nucleoside.
CD74
An antigen, also known as Ii, that is invariant chain of
HLA-class II. It is found on B cells, macrophages, and
some epithelial cells. The expression of CD74 begins during
the pre-B cell stage and is lost before the plasma cell stage.
Several forms (molecular weights of 41, 35, and 33 kDa) are
recognized as arising via alternative splicing.
CD75
A marker of mature B cells expressing surface immunoglobulin
and of a T cell subset but which is also detectable
on epithelial cells. The antigen is lost before the plasma cell
stage. It may be an oligosaccharide.
CD75s
An antigen (molecular weight of 85/67 kDa) that is a marker
of mature B cells expressing surface immunoglobulin and
a T cell subset. The CD76 antigen is lost before the plasma
cell stage. Mantle zone B cells are positive, and germinal
centers are negative. It may be an oligosaccharide.
CD77
A molecule that corresponds to a sugar moiety of globotriaosylceramide
(Gb3) with the formula Galα1-4Galβ1-
4Glc1-1 ceramide and is also recognized as the p k blood
group antigen. The CD77 antigen is only expressed on
activated B cells. It is present on follicular center B cells,
follicular dendritic cells, endothelium, and a variety of
epithelial cell types. Also called BLA.
CDw78 (deleted by VIIth International Workshop)
A pan-B cell and macrophage subset marker that increases
its expression on peripheral B cells after activation. The
CDw78 antigen is expressed on pre-B cells and is lost
before the plasma cell stage. Also called Ba.
CD79a
A 33,40-kDa antigen present on mature B cells. It is part
of the B cell antigen receptor. It is analogous to CD3 in T
cells and is needed for cell-surface expression and signal
transduction. Also called MB1 or Igα.
CD79b
A 33,40-kDa antigen present on mature B cells. It is part
of the B cell antigen receptor and is analogous to CD3 in
T cells. It is needed for cell-surface expression and signal
transduction. Also called B29 or Igβ.
CD80
A 60-kDa antigen present on a B cell subset in vivo and
most activated B cells in vitro. It may also be found on dendritic
cells and macrophages. It serves as a costimulator for
T cell activation. It is a ligand for CTLA-4 and for CD28.
Also called B7 (B7.1) or BB1.
CD81
A 22-kDa antigen present on B cells. It has broad expression
including lymphocytes. It associates with CD19 and
CD21 to produce the B cell coreceptor. This B cell receptor
component also serves as a cell receptor for hepatitis C
virus. Also termed TAPA-1.
CD82
A 50- to 53-kDa antigen. It has broad expression on leukocytes
(weak) but not on erythrocytes. Also called R2, IA4,
or 4F9. Its function is unknown.
CD83
A 43-kDa antigen that serves as a specific marker for
circulating dendritic cells, activated B and T cells, and
germinal center cells. Its function is unknown. Also called
HB15.
CDw84
A 73-kDa antigen present on platelets and monocytes
(strong) and circulating B cells (weak). Its function is
unknown. Also called GR6.
CD85
A 120,83-kDa antigen present on circulating B cells (weak)
and monocytes (strong). Its function is unknown. Also
called VMP-55, GH1/75, or GR4.
CD86
An 80-kDa antigen present on circulation monocytes,
germinal center cells, and activated B cells. Its function is
unknown. Also called FUN-1, GR65, or BU63.
CD87
A 50- to 65-kDa antigen present on monocytes, macrophages,
granulocytes, and activated T cells. It is a urokinase
plasminogen activator receptor. Also called UPA-R
(urokinase plasminogen activator receptor).
CD88
A 42-kDa antigen present on polymorphonuclear leukocytes,
mast cells, macrophages, and smooth muscle cells. It
is a receptor for complement component C5a. Also called
C5a receptor or GR10.
CD89
A 55- to 70-kDa antigen present on neutrophils, monocytes,
macrophages, and T and B cell subpopulations. It is the
receptor for immunoglobulin A (IgA). Also called FcαR,
IgA receptor.
CDw90
A 25- to 35-kDa molecule present on human CD34
prothymocytes, murine thymocytes, and T cells. It is also
expressed on bone marrow, cord blood, and fetal liver. Also
called Thy-1.
CD91
A 600-kD antigen present on monocytes and some nonhematopoietic
cell lines. It is the α 2 macroglobulin receptor
and is also called α 2M-R (α 2 macroglobulin receptor).
CD92
A 70-kDa antigen present on neutrophils, monocytes,
endothelial cells, and platelets. Its function is unknown.
Also called GR9.