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CD56 149 CD71
CD56
A 220/135-kDa molecule that is an isoform of the neural
adhesion molecule (N-CAM). It is used as a marker of
natural killer (NK) cells, but it is also present on neuroectodermal
cells.
CD57
A 110-kDa, myeloid-associated glycoprotein that is recognized
by the antibody HNK1. It is a marker for natural killer
(NK) cells, but it is also found on some T and B cells. It is an
oligosaccharide present on multiple cell surface glycoproteins.
CD58
A 65- to 70-kDa molecule that is a single chain glycoprotein
also known as LFA-3 (leukocyte function associated-3
antigen) and is the ligand to which CD2 binds. The CD58
antigen is expressed on many hematopoietic and nonhematopoietic
cells.
Structure of CD59.
CD59
An 18-kDa membrane glycoprotein that regulates the activity
of the complement membrane attack complex (MAC). A
glycosylphosphatidylinositol anchor attaches CD59 to the outer
layer of the membrane. It is shed from cell surfaces into body
fluid. There is no evidence for a secreted form. CD59 inhibits
MAC formation by binding to sites on C8 and C9, blocking
the uptake and incorporation of multiple C9 molecules into the
complex. CD59 can interact with C8 and C9 from heterologous
species but works best with homologous proteins, which is the
basis for homologous restriction (of lysis). Paroxysmal nocturnal
hemoglobinuria (PNH)-affected cells deficient in C59
and other complement regulatory proteins are very sensitive
to lysis. Also called protective membrane inhibitor of reactive
lysis (MIRL), homologous restriction factor 20 (HRF 20) and
membrane attack complex inhibitory factor (MACIF).
CDw60
An oligosaccharide found on gangliosides. It is present on a
subpopulation of lymphocytes, platelets, and monocytes.
CD61
An antigen that is also termed gpIIIa, the integrin β 3 chain,
or the β chain of the vitronectin receptor (VNR β 3 chain).
GpIIIa can associate with either gpIIb to form the gpIIb/
IIIa complex (CD41) or with the VNR α chain (CD51). The
CD61 molecule has a molecular weight of 110 kDa and is
expressed on platelets and megakaryocytes.
CD62E
A 140-kDa antigen present on endothelium. CD62E is
endothelium leuckocyte adhesion molecule (ELAM). It
mediates neutrophil rolling on the endothelium. It also
binds sialyl–Lewis-x.
CD62L
A 150-kDa antigen present on B and T cells, monocytes,
and natural killer (NK) cells. CD62L is a leukocyte β 3
adhesion molecule (LAM). It mediates cell rolling on
the endothelium and binds CD34 and GlyCAM. It is also
referred to as L-selectin, LECAM-1, or LAM-1.
CD62P
A 75- to 80-kDa antigen present on endothelial cells, platelets,
and megakaryocytes. CD62P is an adhesion molecule
that binds sialyl–Lewis-x. It is a mediator of platelet interaction
with monocytes and neutrophils and also mediates
neutrophil rolling on the endothelium. It is also referred to
as P-selectin, GMP-140, PADGEM, or LECAM-3.
CD63
A 53-kDa antigen that is a platelet-activation antigen associated
with lysosomes. The CD63 molecule is also present on
monocytes, on macrophages, and weakly on granulocytes,
T cells, and B cells. Following activation, the CD63 lysosomal
membrane protein is translocated to the cell surface.
CD64
A 75-kDa receptor that is a single chain glycoprotein. It is a
high-affinity receptor IgG, also known as FcγR1, present on
monocytes and some tissue macrophages.
CDw65
A 180- to 200-kDa fucoganglioside (NeuAc–Gal–GlcNac–
Gal–GlcNac[Fuc]–Gal–GlcNac–Gal–GlcNac–Gal–Glc–
Cer) that is present on granulocytes and monocytes.
CD66a
A 160- to 180-kDa antigen present on cells of neutrophil
lineage. It is also referred to as BGP (biliary glycoprotein).
CD66b
A 95- to 100-kDa antigen present on granulocytes. It is also
referred to as CGM6 (CEA gene member 6), p100. It was
previously called CD67.
CD66c
A 90-kDa antigen present on neutrophils and colon
β 3 carcinoma cells. It is also referred to as NCA (nonspecific
crossreacting antigen).
CD66d
A 30-kDa antigen present on neutrophils. It was formerly
called CGM1 (CEA gene member 1).
CD66e
A 180- to 200-kDa antigen present on adult colon epithelial
cells and colon carcinoma cells. It was previously referred
to as CEA (carcinoembryonic antigen).
CD67
Refer to CD66b.
CD68
A 110-kDa macrophage/myeloid marker that is principally
intracellular but has weak expression under some conditions.
Macrophages, monocytes, neutrophils, basophils, and
large lymphocytes express it. Also called macrosialin.
CD69
A 60-kDa phosphorylated glycoprotein that is a homodimer
of 34/28 kDa. CD69 is also known as AIM (activation
inducer molecule) and is found on activated B and T cells,
activated macrophages, and natural killer (NK) cells.
CD70
A 75-, 95-, 170-kDa antigen present on activated T and B
cells and on Reed–Sternberg cells and weakly expressed on
macrophages. It has also been referred to as Ki-24 antigen
and CD27 ligand.
CD71
A molecule (molecular weight of 95 kDa) that is otherwise
known as transferrin receptor. The antigen is a
C