Untitled - D Ank Unlimited

CD46 148 CD55
CD46
An antigen that is a dimeric protein with a molecular
weight of 66/56 kDa. It has a broad tissue distribution. It is
present on hematopoietic and nonhematopoietic nucleated
cells. The CD46 antigen shows sequence homology to
complement-associated molecules such as decay-accelerating
factor (DAF, CD55) and the complement receptors
CR1 (CD35) and CR2 (CD21). It is a membrane cofactor
protein that binds C3b and C4b, allowing their degradation
by factor I.
CD47
A single chain glycoprotein (molecular weight of 47 to 52
kDa) that is widely distributed and may be associated with
the Rhesus blood group.
CD47R
Formerly CDw149. Mabs actually recognized with low
affinity the CD47 glycoprotein.
CD48
An antigen (molecular weight of 43 kDa) that is a phosphatidylinositol
(PI)-linked glycoprotein and is widely
distributed on white blood cells.
CD49a
A 210-kDa antigen present on activated T cells and
monocytes. It associates with CD29 and binds collagen
and laminin. It is also referred to as VLA-1 and α 1
integrin.
CD49b
A 165-kDa antigen present on B cells, platelets, and
monocytes. It associates with CD29 and binds collagen and
laminin. It is also referred to as VLA-2 and α 2 integrin.
CD49c
A 125-kDa antigen present on B cells. It associates with
CD29 and binds laminin and fibronectin. It is also referred
to as VLA-3 and α 3 integrin.
CD49d
A 150-kDa antigen present on B cells and thymocytes. It associates
with CD29 and binds fibronectin, Peyer’s patch HEV,
and VCAM-1. It is also referred to as VLA-4 and α 4 integrin.
CD49e
A 135,25-dimer antigen present on memory T cells, platelets,
and monocytes. It associates with CD29 and binds
fibronectin. It is also referred to as VLA-5 and α 5 integrin.
CD49f
A 120,25-dimer antigen present on memory T cells, monocytes,
and thymocytes. It associates with CD29 and binds
laminin. It is also referred to as VLA-6 and as α 6 integrin.
CD50
A molecule (molecular weight of 124 kDa) that is broadly
distributed on leukocytes including thymocytes, T cells,
B cells (not plasma cells), monocytes, and granulocytes.
However, it is not present on platelets and erythrocytes.
CD50 is also called ICAM-3.
CD51
A molecule (molecular weight of 140 kDa) that is the α
chain of the vitronectin receptor (VNR). The CD51 antigen
consists of a disulfide-linked large subunit of 125 kDa and a
smaller one of 25 kDa. The VNR α chain is noncovalently
associated with the VNR β 3 chain, also termed gpIIIa or
CD61. The α chain is weakly expressed on platelets. The
VNR mediates cell adhesion to arg–gly–arp-containing
sequences in vitronectin, von Willebrand factor, fibrinogen,
and thrombospondin.
CD51/61 complex
An antigen found on platelets and on endothelial cells. It is
also referred to as vitronectin receptor or as integrin αVβ 3.
CD52
A cluster that corresponds to the leukocyte antigen
(molecular weight of 21 to 28 kDa) recognized by antibody
campath-1. Anti-CD52 antibodies have been used to deplete
T lymphocytes therapeutically.
CD53
A single chain glycoprotein (molecular weight of 32 to 42
kDa) that is widely distributed, for example, in monocytes,
T cells, B cells, and natural killer (NK) cells.
CD54
An intercellular adhesion molecule (ICAM-1) found on
phytohemagglutinin (PHA) blasts, endothelial cells, and
follicular dendritic cells. The molecular weight of the antigen
is 90 kDa. ICAM-1 is a lymphokine-inducible molecule
and has been shown to be a ligand for LFA-1 or the CD11/
CD18 complex. It is also the receptor for rhinovirus. CD54
binds CD11a/CD18 integrin (LFA-1) and CD11b/CD18
integrin (Mac-1).
CD55
A 75-kDa molecule that is a phosphatidylinositol (PI)linked,
single chain glycoprotein, also known as the
decay-accelerating factor (DAF). The antigen is involved
in complement degradation on the cell surface. It is
broadly distributed on hematopoietic and many nonhematopoietic
cells. CD55 binds C3b and disassembles C3/
C5 convertase.
C2
C2
C2
C2
C2
F3
F3
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COOH
Structure of CD56.