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CD23(1B12) 145 CD32
stronger staining. The CD23 molecule may also be a receptor
for B cell growth factor (BCGF).
CD23(1B12)
Anti-CD23 mouse monoclonal antibody. A B-cell antibody
that is useful to differentiate between B-CLL and B-SLLs
that are CD23-positive from mantle cell lymphomas and
small cleaved lymphomas that are CD23-negative. This
antibody reacts with the antigen that is found on a subpopulation
of peripheral blood cells, B lymphocytes, and on
EBV transformed B lymphoblastoid cell lines.
CD24
An antigen that is a glycoprotein found on B cells, granulocytes,
interdigitating cells, and epithelial cells. The CD24
antigen, with a molecular weight of 41/38 kDa, is expressed
on B cells from the late pro-B cell stage and is lost before
the plasma cell stage. It may be a homolog in humans of
murine heat-stable antigen (HSA) or J11d.
CD25
A single chain glycoprotein, often referred to as the α
chain of the interleukin-2 receptor (IL2R) or the Tac antigen,
that has a molecular weight of 55 kDa and is present
on activated T and B cells and activated macrophages. It
functions as a receptor for IL2. Together with the β chain
of the IL2R (p75, molecular weight of 75 kDa), the CD25
antigen forms a high affinity receptor complex for IL2.
The gene for IL2R has been located as a single gene on
chromosome 10. It associates with CD122 and complexes
with the IL2Rβγ high-affinity receptor. It facilitates T cell
growth.
CD26
An antigen (molecular weight of 110 kDa) that is a single
chain glycoprotein. It is present on activated T and B cells
and also on macrophages, bile canaliculi, and splenic
sinusoidal lining cells. It has recently been shown to be a
dipeptidyl peptidase IV (DPP-IV), which is a serine-type
protease, and may play a role in cell proliferation together
with the CD25 antigen. Although the CD4 molecule is
requisite for binding HIV particles, it is not sufficient for
efficient entry of the virus and infection. The cofactor is
dipeptidyl peptidase IV (DPP-IV), also termed CD26.
CD27
A T cell antigen (molecular weight of 110 kDa) that is a
disulfide-linked homodimer of two polypeptide chains,
each with a molecular weight of 55 kDa. It is found on a
subpopulation of thymocytes, on the majority of mature T
cells, and on transformed B lymphocytes. CD27 antigen
expression is unregulated on activated cells.
CD28
A T cell low affinity receptor that interacts with B7 costimlatory
molecules to facilitate T lymphocyte activation. More
specifically, B7-1 and B7-2 ligands are expressed on the surfaces
of activated antigen-presenting cells (APCs). Signals
from CD28 to the T cell elevate expression of high affinity
interleukin-2 (IL2) receptor and increase the synthesis of
numerous cytokines, including IL2. CD28 regulates the
responsiveness of T cells to antigen when they are in contact
with APCs. It serves as a costimulatory receptor because
its signals are synergistic with those provided by the T cell
antigen receptor (TCR-CD3) in promoting T cell activation
and proliferation. Without the signal from TCR-CD3,
the signal of CD28 is only able to stimulate minimal T cell
proliferation and may even lead to T cell unresponsiveness.
CD29
An antigen (molecular weight of 130 kDa) that is very widely
distributed on human tissues (e.g., nerve, connective tissue,
endothelium), as well as on many white cell populations. The
structure recognized is now known to be the platelet gpIIa, the
integrin β-1 chain, the common β subunit of very late antigens
(VLA) 1 to 6, and the fibronectin receptor. The CD29 antigen
is termed gpIIa in contrast to CD31, which is called gpIIa′.
Together with α 1 chain (CDw49), it forms a heterodimeric
complex. CD29 associates with CD49a in VLA-1 integrin.
Antibodies against CD29 appear to define a subset of cells
among CD4-positive T cells which provide help for antibody
production. Like the antibody belonging to CD45RO (UCHL1),
CD29 antibodies appear to be reciprocal (when T4 positive
cells are analyzed) to those of CD45RA antibodies against the
B-cell-restricted form of leukocyte common antigen (LCA).
This form recognizes a T cell subset of CD4-positive cells
suppressing antibody production. The molecule is involved in
the mediation of cell adhesion to cells or matrix, especially in
conjunction with CD49.
CD30
A molecule (molecular weight of 105 kDa) that is a single
chain glycoprotein, also referred to as the Ki-1 antigen,
present on activated T and B cells, embryonal carcinoma
cells, and Hodgkin and Reed–Sternberg cells. It is also
found on a minority of non-Hodgkin lymphomas (referred
to as anaplastic large-cell lymphomas), with a characteristic
anaplastic morphology.
CD31
An antigen (molecular weight of 140 kDa) that is a single
chain membrane glycoprotein. It is found on granulocytes,
monocytes, macrophages, B cells, platelets, and endothelial
cells. Although it is termed gpIIa′, it is different from the
CD29 antigen. At present, its function is unknown. It may
be an adhesion molecule. Also called PECAM-1 (platelet
endothelial cell adhesion molecule-1).
CD32 receptor.
CD32
An antigen (molecular weight of 40 kDa) also known as
FcγRII receptor, which is a low affinity Fc receptor for IgG,
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