Untitled - D Ank Unlimited

CD3 complex 140 CD4
η
HOOC
s s
ZAP-70
ζ ζ ζ
COOH
s s
HOOC
γ
s
s
COOH
COOH COOH COOH
V
s
C2s
V
C2
ε
s
s
COOH
CD3 complex
A combination of α:β or γ:δ T cell receptor chains with the
invariant subunits CD3γ, δ, and ε and the dimeric ζ chains.
CD4
A cell-surface glycoprotein on T cells that recognizes antigens
presented by major histocompatibility complex (MHC)
class II molecules. CD4 binds to the MHC class II molecules
on the antigen-presenting cell and serves as a coreceptor
binding to the lateral faces of the MHC class II molecules.
s
s
s
s
CD3
δ
s
s
Structure of CD3/TCR complex.
ς ς
fyn
Structure of CD4.
TCR
α β
HOOC
TCR: CD3 Complex CD4
α β
s s
s s
ε δ
γ ε
s
s
s
s
s
s
s
s
s
s
s
s
s
s
s s
D 1
D 3
D 4
s s
s s
s s
s s
Ick
COOH
CD45
Structure of TCR/CD3 complex showing the lck, fyn, and ZAP phosphotyrosine
kinases.
D 2
Ribbon structure of T cell surface glycoprotein CD4.
Space-filling model of CD4 type 1 crystal form. Human recombinant form
expressed in Chinese hamster ovary cells.
Ribbon structures of CD4 domains 3 and 4. Rat recombinant form
expressed in Chinese hamster ovary cells.