Untitled - D Ank Unlimited

CD1a 139 CD3
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C1
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β m
shown that the molecule is coded for by at least five genes on
chromosome 1, of which three produce recognized polypeptide
products. CD1 may participate in antigen presentation.
CD1a
An antigen (molecular weight of 49,12 kDa) that is a membrane
glycoprotein. It is expressed strongly on cortical thymocytes.
CD1b
An antigen (molecular weight of 45,12 kDa) that is a membrane
glycoprotein. It is expressed moderately on thymocytes.
CD1c
An antigen (molecular weight of 43,12 kDa) that is a membrane
glycoprotein. It is expressed weakly on cortical thymocytes.
CD2
A T cell adhesion molecule that binds to the LFA-3 adhesion
molecule of antigen-presenting cells. Also called LFA-2.
CD2R
A molecule (molecular weight of 50 kDa) that is restricted
to activated T cells and some natural killer (NK) cells. The
CD2R epitope is unrelated to LFA-3 sites. The antigen is of
importance in T cell maturation, as certain CD2 antibodies
in combination with CD2R antibodies or LFA-3 may induce
T cell proliferation. CD2R is a conformational form of CD2
that is activation-dependent.
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C1
Structure of CD1.
CD2. Ribbon diagram. Resolution = 2.0 Å.
CD2. Space fill. Resolution = 2.0 Å.
CD2. Ribbon structure.
CD3
A molecule, also referred to as the T3 antigen, that consists
of five different polypeptide chains with molecular weights
ranging from 16 to 28 kDa. The five chains are designated
γ, δ, ε, ζ, and ή, with most CD3 antibodies being against the
20-kDa ε chain. They are closely associated physically and
also with the T cell antigen receptor in the T cell membrane.
Incubation of T cells with CD3 antibodies induces
calcium flux and proliferation. This group of molecules
may therefore transmit a signal to the cell interior following
binding of the antigen to the antigen receptor.
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Structure of CD2.
Heterophilic adhesion complex between CD2 and LFA-3..
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