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Botulism immune globulin IV (human) (BIG-IV) 113 BrdU labeling
Daniel Bovet.
acetylcholine. Subsequently, sprouting takes place, and new
terminals are formed that reinnervate the muscle.
Botulism immune globulin IV (human) (BIG-IV)
Indicated for the treatment of patients under 1 year of age
who have infant botulism caused by toxin type A or B.
Bovet, Daniel (1907– 1992)
Primarily a pharmacologist and physiologist, Bovet
received the Nobel Prize in 1957 for his contributions to
the understanding of the role histamine plays in allergic
reactions and the development of antihistamines. (Refer to
Structure chimique et Activite Pharmacodynamique des
Medicaments du Systems Nerveux Vegetatif, 1948; Curare
and Curare-Like Agents, 1959.)
bovine serum albumin (BSA)
Albumin in the sera of cows that is used extensively as an
antigen in experimental immunologic research.
Boyden chamber.
Neutrophil suspension
Micropore filter
Chemotactic solution
Boyden chamber
A two-compartment structure used to assay chemotaxis.
The two chambers in the apparatus are separated by a
micropore filter. The cells to be tested are placed in the
upper chamber and a chemotactic agent such as f–met–leu–
phe is placed in the lower chamber. As cells in the upper
chamber settle to the filter surface, they migrate through the
pores if the agent below chemoattracts them. On staining of
the filter, cell migration can be evaluated.
Active Kinins.
bradykinin
A 9-amino-acid peptide split by plasma kallikrein from
plasma kininogens. It produces slow, sustained, smooth
muscle contraction; its action is slower than that of histamine.
It is produced in experimental anaphylaxis in animal
tissues, and its sequence is Arg–Pro–Pro–Gly–Phe–Ser–
Pro–Phe–Arg. Bradykinin is also increased in endotoxin
shock. Lysyl-bradykinin (kallidin), which is split from
kininogens by tissue kallikreins, also has a lysine residue at
the amino terminus.
brain death
Irreversible loss of brain function without trauma to other
body systems. Artificial maintenance of the subject’s respiration
can be employed to preserve organs for transplantation.
F.W.R. Brambell.
Brambell, F.W.R. (1901–1970)
A pioneer in transmission of immunity from mother to fetus
who described a receptor that conserves IgG by binding to
its Fc region and protects it from catabolism by lysosomes.
It is an Fc receptor that transports IgG across epithelial
surfaces and is named the Brambell receptor.
Brambell receptor (FcRB)
An Fc receptor that transports immunoglobulin G (IgG)
across epithelial surfaces. Its structure resembles that of a
major histocompatibility complex (MHC) class I molecule.
It conserves IgG by binding to its Fc region and protects it
from catabolism by lysosomes. The mechanism of binding
is pH-dependent. In the low pH of the endosomes, the
receptor FcRB binds to IgG. IgG is then transported to the
luminal surface of the catabolic cell, where the neutral pH
mediates release of the bound IgG. Refer to FcRn.
BrdU labeling
A technique to assay cellular proliferation. Based on the incorporation
of bromo-deoxyuridine into the DNA of dividing cells.
B