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enign 104 bentonite (Al 2O 3·4SiO 2·H 2O)<br />

Baruj Benacerraf.<br />

a result of excess synthesis of such chains or from mutant<br />

cells that make only such chains. Both mechanisms appear<br />

operative, and more than 50% of patients with multiple<br />

myeloma, a plasma cell neoplasm, have B–J proteinuria.<br />

The highest frequency of B–J excretion is seen in IgD<br />

myeloma; the lowest is seen in IgG myeloma. The daily<br />

amount excreted parallels the severity of the disease. These<br />

proteins are secreted mostly as dimers and show unusual<br />

heat solubility properties. They precipitate at temperatures<br />

between 40 and 60˚C and redissolve again near 100˚C.<br />

With proper pH control and salt concentration, precipitation<br />

may detect levels as low as 30 mg/100 mL of urine. Better<br />

identification is by protein electrophoresis.<br />

benign<br />

A nonmalignant neoplasm or a mild clinical illness.<br />

benign lymphadenopathy<br />

Lymph node enlargement that is not associated with<br />

malignant neoplasms. Histologic types of benign<br />

lymphadenopathy include nodular, granulomatous,<br />

sinusoidal, paracortical, diffuse or obliterative, mixed,<br />

190<br />

131<br />

C 2<br />

161<br />

202<br />

144<br />

and depleted; clinical states are associated with each<br />

histologic pattern.<br />

benign lymphoepithelial lesion<br />

Autoimmune lesion in lacrimal and salivary glands associated<br />

with Sjögren’s syndrome. Myoepithelial cell aggregates<br />

together with extensive lymphocyte infiltration are present.<br />

benign monoclonal gammopathy<br />

A paraproteinemia that occurs in normal healthy subjects<br />

who develop the serum changes characteristic of myeloma<br />

(i.e., a myeloma protein-type immunoglobulin spike on electrophoresis).<br />

They have none of the clinical signs and symptoms<br />

of multiple myeloma and their prognosis is excellent.<br />

benign tumor<br />

An abnormal proliferation of cells that leads to a growth that<br />

is localized and contained within epithelial barriers. It does<br />

not usually lead to death, in contrast to a malignant tumor.<br />

bentonite (Al 2O 3·4SiO 2·H 2O)<br />

Aluminum silicate that is hydrated and colloidal. This<br />

insoluble particulate substance has been used to adsorb<br />

43<br />

174<br />

112<br />

82<br />

Bence–Jones protein.<br />

14<br />

47<br />

61<br />

N<br />

Bence–Jones protein.<br />

V 2<br />

96<br />

26<br />

68

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