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4-1BB:
A TNF receptor family molecule that binds specifically to
4-1BB ligand.
4-1BB ligand (4-1BBL)
A TNF family molecule that binds to 4-1BB.
selection
The initial principal checkpoint in T cell development. It is
the pathway in which the T cell receptor β chain receptor
expressed by a DN3 thymocyte interacts in a pre-TCR that
enables the thymocyte to receive a survival/proliferation
signal (pre-TCR activation) and become committed to the
αβ T cell lineage.
B-1 cells
B lymphocytes that express the CD5 glycoprotein and
synthesize antibodies of broad specificities. They comprise
a minor population of B cells. Also called CD5 B cells.
B-1a B cells (CD5)
A small population of B cells that express CD5, but to
a lesser degree than CD5 expression on T cells. CD5
is a negative regulator of T cell receptor signaling. It
participates in apoptosis of B-1a cells induced by B cell
receptors.
CTLA-4
B7
B7
CD28
B
Naive T Cell
Antigen presenting cell
Activated T Cell
Antigen presenting cell
B7.
B-2 cells
B lymphocytes that fail to express the CD5 glycoprotein
and synthesize antibodies of narrow specificities. They
comprise most of the B cell population.
b4, b5, b6, and b9
The four alleles whose κ chains vary in multiple constant
region amino acid residues.
B7
A homodimeric immunoglobulin superfamily protein
whose expression is restricted to the surfaces of cells
that stimulate growth of T lymphocytes. The ligand for
B7 is CD28. B7 is expressed on the surfaces of professional
antigen-presenting cells (APCs) and is important in
costimulatory mechanisms. Some APCs may upregulate
expression of B7 following activation by various stimuli,
including IFN-α, endotoxin, and major histocompatibility
complex (MHC) class II binding. B7 is also referred to as
BB1, B7.1, or CD80.
B7.1 costimulatory molecule
A 60-kDa protein that serves as a costimulatory ligand for
CD28 but as an inhibitory ligand upon interacting with
CTLA-4 molecules. Also called CD80.
T-cell
receptor
Antigen
MHC
Class II
CD4
91
B