Chapter 16
Chapter 16
Chapter 16
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Berg • Tymoczko • Stryer<br />
Biochemistry<br />
Seventh Edition<br />
CHAPTER <strong>16</strong><br />
Glycolysis and Gluconeogenesis<br />
Glycolysis – End Results<br />
Glycolysis – End Results<br />
Copyright © 2012 by W. H. Freeman and Company<br />
1
Stoichiometry,<br />
Reactants and<br />
Products<br />
Step One<br />
Glucose Committal<br />
∆G o’ = -<strong>16</strong>.7 kJ/mol<br />
2
Stage I<br />
Energy<br />
Utilization<br />
Priming and<br />
Fragmentation<br />
Stage II<br />
Energy<br />
Production<br />
Phosphoglucose Isomerase<br />
∆G o’ = +1.7 kJ/mol<br />
3
∆G o’ = -14.2 kJ/mol<br />
∆G o’ = +23.8 kJ/mol<br />
∆G o’ = +7.5 kJ/mol<br />
4
Triose Phosphate<br />
Isomerase<br />
Triose Phosphate Isomerase<br />
Note: All Steps in Stage II<br />
Note: All Steps in Stage II<br />
are Doubled<br />
5
+49.4 kJ<br />
+61.8 kJ<br />
-104.9 kJ<br />
∆G o’ = +6.3 kJ/mol<br />
Glyceraldehyde-3-phosphate Dehydrogenase<br />
A Multi-step Reaction<br />
6
Glyceraldehyde-3-phosphate Dehydrogenase<br />
A Multi-step Reaction<br />
Glyceraldehyde-3phosphate<br />
Dehydrogenase<br />
A Multi-step Reaction<br />
7
∆G o’ = +1.7 kJ/mol<br />
∆G o’ = +4.6 kJ/mol<br />
∆G o’ = -18.8 kJ/mol<br />
Pyruvate Kinase<br />
∆G o’ = -31.4 kJ/mol<br />
∆G o’ = -31.4 kJ/mol<br />
8
Key to glycolysis<br />
continuance is NAD +<br />
regeneration.<br />
Overall balanced<br />
reaction and<br />
standard free energy<br />
change?<br />
9
TPP<br />
10
Biotin<br />
17
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