Magnetic Separation: Industrial and Lab Scale Applications

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Labeled cells, i.e. neural progenitor cells (Lewin 2000 Nature Biotech), red blood cells (Haukanes 1993 Nature Biotech, Takayasu 2000, Zborowski 2003 BiophysicalJ, Seesod 1997 Am J Trop Med Hyg), tumor cells (Wang 2004 NanoLett), malarial parasites (Melville 1981 IEEE), baker’s yeast (Azevedo 2003 IEEE), can be targeted to magnetic beads which can therefore be separated (Pankhurst 2003). Magnetic moment or giant magnetoresistance of the magnetic particle-cell assembly can tell us about the location and even the count of the cells that are present (Pankhurst 2003). With efforts to take magnetic cell separation to industrial level, Berger and coworkers were able to develop a micro cell separator (Berger 2001 Electrophoresis), Haik introduced a magnetic device for continuous separation of red blood cells (Haik 1999 JMMM) and Zborowski applied a magnetic quadrupole flow sorter on a model cell system of human peripheral lymphocytes targeted with commercial monoclonal antibodies and iron-dextran colloid (Zborowski 1999 JMMM). Figure 14 and 15 shows two examples of magnetic devices for cell separations. Recently, magnetic nanowires were experimented with cell separation techniques and found to be four times better in purity (80 %) and recovery (85%) yields (Hultgren 2004 IEEE).
Figure 14. Magnetically labeled cells can be separated on a gravity feed through a high gradient magnetic separator (HGMS). From ref (Berger 2001 Electrophoresis)
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Magnetic Separation: Industrial and Lab Scale Applications

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