Brain Tumor and Neuro-Oncology Center - Cleveland Clinic

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4 Executive Summary Cleveland Clinic Brain Tumor and Neuro-Oncology Center enjoyed a year of substantial accomplishment in 2008. Record-Setting Clinical and Financial Performance: • 7,943 outpatient visits • 936 surgical, Gamma Knife ® and Novalis ® procedures • Increase of 150% new patient visits, 366% total outpatient visits, 23% surgical cases and 91% Gamma Knife cases since program’s inception in 2001 • Largest market share in Ohio • 21% increase in net revenue and 85% increase in contribution margin over 2007 Solid Research Revenue and Philanthropic Support: • Funding through three federal grants • $1.5M in philanthropic support since 2007 and $14.6M since inception Pace-Setting Clinical Programs: • World’s first human treatment of brain tumor using AutoLITT ® thermal therapy system (see cover figure) • Advance navigation using DTI and fMRI planning and intraoperative visualizations • Compact MRI with development of high-field interventional MRI operating room • Leader in convection-enhanced delivery of advanced agents to brain tumors • Second Gamma Knife Perfexion unit in North America – 317 cases in 2008 • Leader in spinal radiosurgery – 74 procedures performed in 2008, and more than 200 cases since program inception in 2004 • Integration of neuropsychology into clinical program BRAIN TUMOR AND NEURO-ONCOLOGY CENTER Robust Clinical Research: • Completing membership in NCI-sponsored New Approaches to Brain Tumor Therapy (NABTT) consortium • Charter member of NCI-sponsored Adult Brain Tumor Consortium (ABTC), commencing in 2009 • Leadership in national brain tumor organizations • Dr. Vogelbaum Scientific Program Chair of 2008 Society of Neuro-Oncology Meeting Laboratory Research: • Recruitment of Jeremy Rich, MD, as Chair of Genomics Institute. Dr. Rich, a world-renowned expert on brain tumor stem cells, joined the professional staff in September 2008. • Recruitment of Candece Gladson, PhD, as Head of Brain Tumor Laboratory Research in the Department of Cancer Biology of Cleveland Clinic Lerner Research Institute. Dr. Gladson joined the staff in January 2009. • Primary labs and collaborations performing cuttingedge basic and translational research Education – Local, Regional, National and International Presence: • Hosted Second International Symposium on Stereotactic Body Radiation Therapy and Stereotactic Radiosurgery • Hosted Pituitary Disease Symposium in April • Hosted joint meeting with Mexican Neurosurgical and Neuro-Oncology Societies in November at Los Cabos, Mexico • Hosted four Gamma Knife hands-on courses Publishing Our Accomplishments: • BTNC staff published 38 journal articles and two book chapters in 2008
2008 ANNUAL REPORT Brain Tumor and Neuro-Oncology Center – Overview A Team Approach to Individualized Care Cleveland Clinic Brain Tumor and Neuro-Oncology Center (BTNC) is a national leader in the diagnosis, treatment and research of brain tumors. The unique administrative structure of the BTNC allows our multidisciplinary team of physicians and scientists to focus almost exclusively on brain tumors, facilitating opportunities for our staff to participate in international research protocols, share information about the latest developments in the field and combine therapeutic approaches from a number of disciplines. The result is the ability to bring the most promising new treatments to the clinical realm in an environment that facilitates individualized patient care. The BTNC has been a member of the prestigious New Approaches to Brain Tumor Therapy (NABTT) consortium for more than seven years. The primary objective of the National Cancer Institute-sponsored NABTT consortium is to improve the therapeutic outcome for adults with primary brain tumors while sharing human brain tumor specimens and clinical and laboratory data to facilitate additional research pertaining to basic biology and neuro-pharmacology of new treatments. To qualify for NABTT membership, an institution must possess strong clinical and research programs for adult brain tumors, expert multidisciplinary clinical teams, extensive laboratory and clinical resources, and the ability to conduct high-quality, clinically relevant trials. In 2008, we were honored to be selected as a charter member of the new Adult Brain Tumor Consortium, which supersedes the NABTT consortium in 2009. Building on the strong tradition of excellence and innovation established by members of the BTNC team, the future of clinical application and ongoing research at Cleveland Clinic is both bright and exciting. We aim to streamline the process of bringing potentially groundbreaking therapeutic agents from the laboratory to the patient, making new chemotherapeutic agents, radiosurgical techniques and surgical procedures available more quickly, while maintaining the highest scientific standards for both efficacy and safety. 5
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