36 Appendix A – <strong>Clinic</strong>al Trials (Adult) (continued) IRB BRAIN TUMOR AND NEURO-ONCOLOGY CENTER 7161 Phase I Study of Convection Enhanced Delivery (CED) Of IL13-PE38QQR Infusion after Resection Followed by Radiation Therapy with or without Temozolomide in Patients with New Diagnosed Supratentorial Malignant Glioma CC311 CLDX 1307 Vogelbaum Phase II/III R<strong>and</strong>omized Study of CDX-110 with Radiation & Temozolomide in Patients with Newly Diagnosed GBM Vogelbaum CC429 Phase II, Multicenter, Exploratory Study, Evaluating the Treatment Effect of Surgery Plus GLIADEL Wafer in Patients with Metastatic <strong>Brain</strong> Cancer MGI 1307 Phase II, Multicenter, Exploratory Study, Evaluating the Treatment of Surgery Plus GLIADEL Wafer in Patients with Metastatic <strong>Brain</strong> Cancer 7003 Phase I/II Study Utilizing the PEC Intraoperative Radiotherapy Device for the Treatment of a Resected Solitary <strong>Brain</strong> Metastasis CC126 A Prospective, Multi-center Trial of NovoTTF-100A Compared to Best St<strong>and</strong>ard of Care in Patients with Progressive or Recurrent GBM CC385 CASE 4107 COOPERATIVE GROUP Vogelbaum Vogelbaum <strong>Clinic</strong>al Study to Assess Entry of Chemotherapeutic Agents into <strong>Brain</strong> Metastases in Women with Breast Cancer Weil Pediatric Trials: COG (Children’s <strong>Oncology</strong> Group) TITLE PI PROTOCOL TITLE PI ACNS0232 Radiotherapy vs. Chemotherapy in CNS Germinoma Tekautz T; Wiersma S ACNS0331 RT <strong>and</strong> Chemotherapy in Medulloblastoma Tekautz T. ACNS0423 Phase II Rx Radiation <strong>and</strong> Temozolomide <strong>and</strong> Temozolomide <strong>and</strong> CCNU in High Grade Gliomas Tekautz T; Wiersma S ACNS0334 Phase III R<strong>and</strong>omized Trial for the Treatment of Newly Diagnosed Supratentorial PNET <strong>and</strong> High Risk Medulloblastoma in Children
2008 ANNUAL REPORT Appendix B – Publications Journal Publications Angelov L. Stereotactic spine radiosurgery. Spinal Column 2008 Spring;14-15. Bain M, Moheet AM, Rasmussen P. Which patients benefit from carotid stenting? What recent trials show. Cleve Clin J Med 2008 Oct;75(10):714-720. Balmaceda C, Peereboom D, Pannullo S, Cheung YKK, Fisher PG, Alavi J, Sisti M, Chen J, Fine RL. Multi-institutional phase II study of temozolomide administered twice daily in the treatment of recurrent high-grade gliomas. Cancer 2008 Mar 1;112(5):1139-1146. Brat DJ, Parisi JE, Kleinschmidt-Demasters BK, Yachnis AT, Montine TJ, Boyer PJ, Powell SZ, Prayson RA, McLendon RE. Surgical neuropathology update: a review of changes introduced by the WHO classification of tumours of the central nervous system, 4th edition. Arch Pathol Lab Med 2008 Jun;132(6):993-1007. Brat DJ, Prayson RA, Ryken TC, Olson JJ. Diagnosis of malignant glioma: role of neuropathology. J <strong>Neuro</strong>oncol 2008 Sep;89(3):287-311. Buatti J, Ryken TC, Smith MC, Sneed P, Suh JH, Mehta M, Olson JJ. Radiation therapy of pathologically confirmed newly diagnosed glioblastoma in adults. J <strong>Neuro</strong>oncol 2008 Sep;89(3):313-337. Chamberlain WA, Prayson RA. Focal cortical dysplasia type II (malformations of cortical development) aberrantly expresses apoptotic proteins. Appl Immunohistochem Mol Morphol 2008 Oct;16(5):471-476. Chao ST, Barnett GH, Vogelbaum MA, Angelov L, Weil RJ, Neyman G, Reuther AM, Suh JH. Salvage stereotactic radiosurgery effectively treats recurrences from whole-brain radiation therapy. Cancer 2008 Oct 15;113(8):2198-2204. Daneshvar H, Nelms J, Muhammad O, Jackson H, Tkach J, Davros W, Peterson T, Vogelbaum MA, Bruchez MP, Toms SA. Imaging characteristics of zinc sulfide shell, cadmium telluride core quantum dots. Nanomed 2008 Feb;3(1):21-29. Das T, Sa G, Paszkiewicz-Kozik E, Hilston C, Molto L, Rayman P, Kudo D, Biswas K, Bukowski RM, Finke JH, Tannenbaum CS. Renal cell carcinoma tumors induce T cell apoptosis through receptor-dependent <strong>and</strong> receptor-independent pathways. J Immunol 2008 Apr 1;180(7):4687-4696. Das T, Sa G, Hilston C, Kudo D, Rayman P, Biswas K, Molto L, Bukowski R, Rini B, Finke JH, Tannenbaum C. GM1 <strong>and</strong> tumor necrosis factor-alpha, overexpressed in renal cell carcinoma, synergize to induce T-cell apoptosis. Cancer Res 2008 Mar 15;68(6):2014-2023. Elkassabany NM, Bhatia J, Deogaonkar A, Barnett GH, Lotto M, Maurtua M, Ebrahim Z, Schubert A, Ference S, Farag E. Perioperative complications of blood brain barrier disruption under general anesthesia: a retrospective review. J <strong>Neuro</strong>surg Anesthesiol 2008 Jan;20(1):45-48. Finke JH, Goel M. T-cell unresponsiveness in renal cell carcinoma patients. In: Bukowski RM, Novick AC, eds. <strong>Clinic</strong>al management of renal tumors. Totowa, NJ: Humana Press; 2008. Chapter 7. p. 115-130. Finke JH, Rini B, Irel<strong>and</strong> J, Rayman P, Richmond A, Golshayan A, Wood L, Elson P, Garcia J, Dreicer R, Bukowski R. Sunitinib reverses type-1 immune suppression <strong>and</strong> decreases T-regulatory cells in renal cell carcinoma patients. Clin Cancer Res 2008 Oct 15;14(20):6674-6682. Fitzgerald DP, Palmieri D, Hua E, Hargrave E, Herring JM, Qian Y, Vega-Valle E, Weil RJ, Stark AM, Vortmeyer AO, Steeg PS. Reactive glia are recruited by highly proliferative brain metastases of breast cancer <strong>and</strong> promote tumor cell colonization. Clin Exp Metastasis 2008;25(7):799-810. Fu P, van Heeckeren WJ, Wadhwa PD, Bajor DJ, Creger RJ, Xu Z, Cooper BW, Laughlin MJ, Gerson SL, Koc ON, Lazarus HM. Time-dependent effect of non-Hodgkin’s lymphoma grade on disease-free survival of relapsed/refractory patients treated with high-dose chemotherapy plus autotransplantation. Contemp Clin Trials 2008 Mar;29(2):157-164. George S, Hutson TE, Mekhail T, Wood L, Finke J, Elson P, Dreicer R, Bukowski RM. Phase I trial of PEG-interferon <strong>and</strong> recombinant IL-2 in patients with metastatic renal cell carcinoma. Cancer Chemother Pharmacol 2008 Jul;62(2):347-354. Georgitsi M, De Menis E, Cannavo S, Makinen MJ, Tuppurainen K, Pauletto P, Curto L, Weil RJ, Paschke R, Zielinski G, Wasik A, Lubinski J, Vahteristo P, Karhu A, Aaltonen LA. Aryl hydrocarbon receptor interacting protein (AIP) gene mutation analysis in children <strong>and</strong> adolescents with sporadic pituitary adenomas. Clin Endocrinol (Oxf ) 2008 Oct;69(4):621-627. Gibson SE, Zeng WF, Weil RJ, Prayson RA. Aurora B kinase expression in ependymal neoplasms. Appl Immunohistochem Mol Morphol 2008 May;16(3):274-278. Grossman SA, Carson KA, Phuphanich S, Batchelor T, Peereboom D, Nabors LB, Lesser G, Hausheer F, Supko JG. Phase I <strong>and</strong> pharmacokinetic study of karenitecin in patients with recurrent malignant gliomas. <strong>Neuro</strong> Oncol 2008 Aug;10(4):608-616. 37