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CURRICULUM VITAE<br />

Name: <strong>Herbert</strong> T. <strong>Nagasawa</strong><br />

Place of Birth: Hilo, Hawaii<br />

Education:<br />

B.S. 1950 Western Reserve University, Cleveland, OH<br />

Major: Chemistry<br />

Minor: Mathematics<br />

Honors: Phi Society (Honorary Scholastic)<br />

Ph.D. 1955 University of Minnesota, Minneapolis, MN<br />

Major: Organic Chemistry<br />

Minor: Analytical Inorganic and Physical Chemistry<br />

Honors: Phi Lambda Upsilon (Chemistry Scholastic)<br />

Post-Doctoral 1955- Department of Biochemistry, University of Minnesota,<br />

Fellow 1957 Minneapolis, MN<br />

Honors: Sigma Xi (Scientific Research)<br />

Military Service:<br />

1945 - 1947 Military Intelligence Service, U.S. Army<br />

Positions Held:<br />

1951 - 1954 Teaching Assistant, Department of Chemistry, University of<br />

Minnesota, Minneapolis, MN<br />

1954 - 1955 Pre-doctoral Fellow, Allied Chemical & Dye Corp., Department of<br />

Chemistry, University of Minnesota, Minneapolis, MN<br />

1955 - 1957 Post-doctoral Fellow, Department of Biochemistry, University of<br />

Minnesota, Minneapolis, MN<br />

1957-1961 Senior Chemist, Radioisotope Service Research Laboratory,<br />

Veterans Administration Medical Center, Minneapolis, MN<br />

1961-1978 Senior Scientist, Laboratory for Cancer Research, Veterans<br />

Administration Medical Center, Minneapolis, MN<br />

1961 - 1976 Principal Scientist, General Medical Research, Veterans<br />

Administration Medical Center, Minneapolis, MN<br />

1961 - 1981 Member and Basic Science Representative, Research and<br />

Education Committee, Veterans Administration Medical Center,<br />

Minneapolis, MN<br />

1978 - 2002 Senior Research Career Scientist, Veterans Administration<br />

MedicalCenter, Minneapolis, MN<br />

2002 - 2004 Senior Medical Research Scientist, Veterans Administration<br />

Medical Center, Minneapolis, MN


1959 - 1963 Assistant Professor, Pharmaceutical Chemistry, University of<br />

Minnesota, Minneapolis, MN<br />

1963 - 1972 Associate Professor, Medicinal Chemistry, University of Minnesota,<br />

Minneapolis, MN<br />

1973 - 2004 Professor, Medicinal Chemistry, University of Minnesota,<br />

Minneapolis, MN (Officially retired 6/04)<br />

1987 - 1995 Professor, Pharmacology, University of Minnesota, Minneapolis,<br />

MN<br />

1990 - 2004 Professor, Toxicology, University of Minnesota, Duluth, MN<br />

(Officially retired 6/04)<br />

2004-2007 Member, Center for Drug Design, Academic Health Center,<br />

University of Minnesota<br />

2007-to date Adjunct Professor, Center for Drug Design, Academic Health<br />

Center, University of Minnesota<br />

1972 - 1984 Associate Editor, Journal of Medicinal Chemistry, American<br />

Chemical Society (Acting Editor: 8/73 to 6/74)<br />

1985 - 2004 Senior Editor, Journal of Medicinal Chemistry, American Chemical<br />

Society (Retired 6/04)<br />

1974 - 1977 Member, Health Sciences Policy and Review Council, University of<br />

Minnesota Graduate School, Minneapolis, MN<br />

1976 - 1978 Chairperson, Biomedical Research Committee, Alcohol and Other<br />

Drub Abuse Program (AODAP), University of Minnesota,<br />

Minneapolis, MN<br />

1983 - 1984 AODAP Biomedical Grants Review Committee, University of<br />

Minnesota, Minneapolis, MN<br />

1980 - 1981 Ad Hoc Member, Initial Review Group (IRG), Biomedical Research<br />

Review Committee, Alcohol, Drug Abuse and Mental Health<br />

Administration (ADAMHA)<br />

1984 - 1985 Member, Special Review Committee, "National Cooperative Drug<br />

Discovery Group (NCDDG)", National Cancer Institute, National<br />

Institutes of Health (NIH)<br />

1985 Judge, Third Annual Graduate Student Awards, Mechanisms<br />

Section, Society of Toxicology<br />

1990 Visiting Professor, College of Pharmacy, Washington State<br />

University, Pullman, WA (March 24-31)<br />

1990 - 1997 Editorial Board, Bioconjugate Chemistry, American Chemical<br />

Society<br />

Professional Societies:<br />

American Academy of Anti-Aging Medicine (A 4 M)<br />

American Chemical Society (ACS)<br />

American Society for Pharmacology and Experimental Therapeutics (ASPET)<br />

American Association for Cancer Research (AACR)<br />

American Association for the Advancement of Science (AAAS)


International Society for Biomedical Research on Alcoholism (ISBRA)<br />

International Society for the Study of Xenobiotics (ISSX)<br />

New York Academy of Sciences (NYAS): Elected as Fellow, 1983<br />

Research Society on Alcoholism (RSA)<br />

Society of Toxicology (SOT)<br />

Nitric Oxide Society<br />

Listed: American Men and Women of Science; Who's Who in the Midwest<br />

Graduate Faculty Appointment:<br />

Medicinal Chemistry: B Appointment (Full Member)<br />

Pharmacology: A Appointment (Associate Member)<br />

Toxicology: B Appointment (Full Member)<br />

Research Interests: Design and synthesis of a) trapping agents for the detoxification of<br />

xenobiotic substances that are activated to toxic metabolites in vivo, b) latentiated<br />

(prodrug) forms of biologically active substances such as nitroxyl (HNO), c) prodrugs of<br />

cysteine and glutathione as protective agents for cellullar oxidative stress, and d)<br />

cyanide antidotes based on β-mercaptopyruvate.


Publications<br />

<strong>Nagasawa</strong>, H. T. Ph.D. Thesis, Studies in Polypeptide Synthesis: Some Polyglycyl<br />

Derivatives of Desoxyephedrine. University of Minnesota 1955.<br />

<strong>Nagasawa</strong>, H. T.; Gutmann, H. R. On the Acylation of the Carcinogen, 2-<br />

Aminofluorene, by Rat Liver In Vitro. Biochim. Biophys. Acta 1957, 24, 631-632.<br />

<strong>Nagasawa</strong>, H. T.; Gutmann, H. R. A Note on the Deacylation of the Carcinogen, 2-<br />

Acetamidofluorene and Related Compounds by Rat Liver and Intestine. Biochim.<br />

Biophys. Acta 1957, 25, 186-189.<br />

Gutmann, H. R.; Burtle, J. G.; <strong>Nagasawa</strong>, H. T. Protein Binding of Model Quinone<br />

Imides. I. The Synthesis of Some Fluorenoquinone Imides. J. Am. Chem. Soc. 1958,<br />

80, 5551-5555.<br />

<strong>Nagasawa</strong>, H. T.; Morgan, M. A.; Gutmann, H. R. The Enzymatic Oxidation of o-<br />

Aminophenols. Biochim. Biophys. Acta 1958, 28, 665-666.<br />

<strong>Nagasawa</strong>, H. T.; Gutmann, H. R. Preparation and Properties of S-Acetyl-Nbenzoylcysteamine.<br />

J. Org. Chem. 1958, 23, 487.<br />

<strong>Nagasawa</strong>, H. T.; Gutmann, H. R. The Oxidation of o-Aminophenols by Cytochrome c<br />

and Cytochrome Oxidase. I. Enzymatic Oxidations and Binding of Oxidation Products<br />

to Bovine Serum Albumin. J. Biol. Chem. 1959, 234, 1593-1599.<br />

<strong>Nagasawa</strong>, H. T.; Gutmann, H. R. The Oxidation of o-Aminophenols by Cytochrome c<br />

and Cytochrome Oxidase. III. 2,3-Fluorenoquinone from 2-Amino-3-fluorenol and<br />

Binding of Quinonoid Oxidation Products to Bovine Serum Albumin. J. Biol. Chem.<br />

1960, 235, 3466-3471.<br />

Alexander, C. S.; <strong>Nagasawa</strong>, H. T.; Filbin, D. Disribution and Excretion of<br />

Aminonucleoside-8-C 14 in Normal and Nephrotic Rats. Proc. Soc. Exp. Biol. Med. 1962,<br />

111, 521-526.<br />

Alexander, C. S.; Hunt, V. R.; <strong>Nagasawa</strong>, H. T. Dose-Response Relationship in<br />

Aminonucleoside Nephrosis. Proc. Soc. Exp. Biol. Med. 1963, 112, 506-510.<br />

Alexander, C. S.; <strong>Nagasawa</strong>, H. T. Aminonucleoside of Puromycin: Elimination of<br />

Nephrotoxicity by Acetylation of the Aminoribose Moiety. Biochem. Pharmacol. 1964,<br />

13, 548-551.<br />

<strong>Nagasawa</strong>, H. T.; Osteraas, A. J. The Biological Arylation of Proteins In Vitro by a<br />

Metabolite of the Carcinogen, N-2-Fluorenylacetamide. Biochem. Pharmacol. 1964, 13,<br />

713-723.


Dickie, N.; Alexander, C. S.; <strong>Nagasawa</strong>, H. T. Inhibition of Nucleic Acid Synthesis in<br />

Escherichia coli B by Puromycin Aminonucleoside. Biochim. Biophys. 1965, 95, 156-<br />

169.<br />

Derr, R. F.; Alexander, C. S.; <strong>Nagasawa</strong>, H. T. An Interaction Between Aminopurines,<br />

Aminopyrimidines and Fluorescent Thin-Layer Plates. J. Chromatogr. 1966, 21, 146-<br />

147.<br />

Dickie, N.; Norton, L. F.; Derr, R. F.; Alexander, C. S.; <strong>Nagasawa</strong>, H. T. The Effect of<br />

Puromycin Aminonucleoside on the Incorporation of Labeled Precursors into Rat Kidney<br />

RNA. Biochim. Biophys. 1966, 129, 288-293.<br />

Dickie, N.; Norton, L. F.; Derr, R. F.; Alexander, C. S.; <strong>Nagasawa</strong>, H. T. The Inhibition<br />

of Adenosine Deaminase by a Metabolite of the Nephrotoxic Drug, Puromycin<br />

Aminonucleoside. Proc. Soc. Exp. Biol. Med. 1966, 123, 421-423.<br />

<strong>Nagasawa</strong>, H. T.; Gutmann, H. R. Ortho-methoxy Derivatives of the Carcinogen, N-2-<br />

Fluorenylacetamide: Latent Biological Arylating Agents. J. Med. Chem. 1966, 9, 719-<br />

725.<br />

<strong>Nagasawa</strong>, H. T.; Elberling, J. A. Synthesis of Ring Homologs of Proline by the<br />

Favorskii Rearrangement of -Halolactams. Tetrahedron Lett. 1966, 44, 5393-5399.<br />

Alexander, C. S.; Swingle, K. F.; <strong>Nagasawa</strong>, H. T. Tetratogenic Effect of Puromycin<br />

Aminonucleoside on Rat Kidney. Nephron 1966, 3, 344-351.<br />

<strong>Nagasawa</strong>, H. T.; Swingle, K. F.; Alexander, C. S. Metabolism of Aminonucleoside-8-<br />

C 14 in the Rat and Guinea Pig. Biochem. Pharacol. 1967, 16, 2211-2219.<br />

Derr, R. F.; Alexander, C. S.; <strong>Nagasawa</strong>, H. T. The Metabolism of Puromycin<br />

Aminonucleoside in the Normal, "Pre-nephrotic" and Nephrotic Rat. Proc. Soc. Exp.<br />

Biol. Med. 1967, 125, 248-252.<br />

<strong>Nagasawa</strong>, H. T.; Alexander, C. S.; Swingle, K. F. Inhibition of Aminonucleoside<br />

Nephrosis in Rats. The Lack of Effect of Hepatic Drug Metabolizing Enzyme Inhibitors<br />

and Stimulators on Nephrotoxicity. Toxicol. Appl. 1967, 11, 336-345.<br />

Derr, R. F.; Loechler, D. K.; Alexander, C. S.; <strong>Nagasawa</strong>, H. T. Inhibition of Rat Liver<br />

Microsomal N-Demethylase by -Naphthylisothiocyanate: Studies with Puromycin<br />

Aminonucleoside. Proc. Soc. Exp. Biol. Med. 1967, 126, 844-845.<br />

Derr, R. F.; Loechler, D. K.; Alexander, C. S.; <strong>Nagasawa</strong>, H. T. Metabolism of<br />

Aminonucleoside-8-C 14 in the Mouse. The Relationship Between Metabolism and<br />

Experimental Nephrosis. Biochem. Pharmacol. 1968, 17, 265-268.


Derr, R. F.; Loechler, D. K.; Alexander, C. S.; <strong>Nagasawa</strong>, H. T. Inhibition of<br />

Aminonucleoside Nephrosis in Rats. IV. Prevention of N 6 -Methyladenosine. J. Lab.<br />

Clin. Med. 1968, 72, 363-369.<br />

<strong>Nagasawa</strong>, H. T.; Fraser, P. S.; Elberling, J. A. Chromatographic Properties of Some<br />

Cyclic -Imino Acids Homologous to Proline, and their DNP-, DNS- AND PTH-<br />

derivatives. J. Chromatogr. 1969, 44, 300-306.<br />

<strong>Nagasawa</strong>, H. T.; Alexander, C. S.; Shirota, F. N.; Ghobrial, H.; Swingle, K. F.; Derr, R.<br />

F. Metabolic Basis for the Lack of Nephrotoxicity of Acetylated Puromycin<br />

Aminonucleoside in Rats. Toxicol. Appl. Pharmacol. 1970, 16, 1-9.<br />

Derr, R. F.; Aaker, A.; Alexander, C. S.; <strong>Nagasawa</strong>, H. T. Synergism Between Cobalt<br />

and Ethanol on Rat Growth Rate. J. Nutr. 1970, 100, 521-524.<br />

<strong>Nagasawa</strong>, H. T.; Elberling, J. A.; Fraser, P. S.; Mizuno, N. S. Medium Ring Homologs<br />

of Proline as Potential Amino Acid Antimetabolites. J. Med. Chem. 1971, 14, 501-508.<br />

<strong>Nagasawa</strong>, H. T.; Shirota, F. N.; Alexander, C. S. Identification and Synthesis of the<br />

Major Nucleoside Metabolite in Rabbit Urine After Administration of Puromycin<br />

Aminonucleoside. J. Med. Chem. 1972, 15, 177-181.<br />

<strong>Nagasawa</strong>, H. T.; Fraser, P. S.; Elberling, J. A. N-Phenyl-2-thio-1,2-azetidinecarboximide,<br />

the Phenylthiogydantoin of Azetidine-2-carboxylic Acid. J. Org. Chem.<br />

1972, 37, 516-519.<br />

<strong>Nagasawa</strong>, H. T.; Shirota, F. N.; Matsumoto, H. Decomposition of<br />

Methylazoxylmethanol, the Agycone of Cycasin, in D2O. Nature 1972, 236, 234-235.<br />

Elberling, J. A.; <strong>Nagasawa</strong>, H. T. The Twelve- to Fifteen-Membered Ring Homologs of<br />

Proline. J. Heterocycl. Chem. 1972, 9, 411-414.<br />

<strong>Nagasawa</strong>, H. T.; Kohlhof, J. G.; Fraser, P. S.; Mikhail, A. A. Sythesis of 1-Hydroxy-Lproline<br />

and Related Cyclic N-Hydroxyamino Acids. Metabolic Disposition of 14 C-<br />

Labeled 1-Hydroxy-L-proline in Rodents. J. Med. Chem. 1972, 15, 483-486.<br />

<strong>Nagasawa</strong>, H. T.; Thompson, J. A. Reactions of Interest in Medicinal Chemistry. In<br />

Annual Reports in Medicinal Chemistry, Chapter 25, Vol. 7; Heinzelman, R., Ed.;<br />

Academic Press: New York, NY, 1972, pp. 269-279.<br />

<strong>Nagasawa</strong>, H. T.; Fraser, P. S.; Yuzon, D. L. A New Method for Nitrosation of Proline<br />

and Related Secondary- -Amino Acids to N-Nitrosamine with Possible Oncogenic<br />

Activity. J. Med. Chem. 1973, 16, 583-585.


<strong>Nagasawa</strong>, H. T.; Elberling, J. A.; Shirota, F. N. 2-Aminoadamantane-2-carboxylic Acid,<br />

A Rigid, Achiral, Tricyclic - -Amino Acid with Transport Inhibitor Properties. J. Med.<br />

Chem. 1973, 16, 823-826.<br />

Forsyth, G. W.; <strong>Nagasawa</strong>, H. T.; Alexander, C. S. Acetaldehyde Metabolism by the<br />

Rat Heart. Proc. Soc. Exp. Biol. Med. 1973, 144, 498-500.<br />

<strong>Nagasawa</strong>, H. T.; Fullerton, D. S. Reactions of Interest in Medicinal Chemistry. In<br />

Annual Reports in Medicinal Chemistry, Chapter 31, Vol. 8; Heinzelman, R., Ed.;<br />

Academic Press: New York, NY, 1973, pp. 303-312.<br />

<strong>Nagasawa</strong>, H. T.; Shirota, F. N.; Mizuno, N. S. The Mechanisms of Alkylation of DNA<br />

by 5-(3-Methyl-1-triazeno)imidazole-4-carboxamide (MIC), a Metabolite of DIC (NSC-<br />

45388). Non-involvement of Diazomethane. Chem. Biol. Interact. 1974, 8, 403-413.<br />

Thompson, R. D.; <strong>Nagasawa</strong>, H. T.; Jenne, J. W. The Determination of Theophylline<br />

and Its Metabolites in Human Urine and Serum by High Pressure Liquid<br />

Chromatography. J. Lab. Clin. Med. 1974, 84, 584-593.<br />

<strong>Nagasawa</strong>, H. T.; Elberling, J. A.; Shirota, F. N. Potential Latentiation Forms of<br />

Biologically-Active Compounds Based on Action of Leucine Aminopeptidase. Dipeptide<br />

Derivatives of the Tricycloaliphatic -Amino Acid, Adamantanine. J. Med. Chem. 1975,<br />

18, 826-830.<br />

Shirota, F. N.; <strong>Nagasawa</strong>, H. T. Synthesis of Ethambutol- 14 C Dihydrochloride [(+)-N,N'bis(1-Hydroxy-2-butyl)ethylene-U-<br />

14 C-diamine Dihydrochloride]. J. Labelled Compd.<br />

1975, 11, 457-459.<br />

Jenne, J. W.; <strong>Nagasawa</strong>, H. T.; McHugh, R.; MacDonald, F.; Wyse, E. Decreased<br />

Theophylline Half-life in Cigarette Smokers. Life Sci. 1975, 17, 195-198.<br />

<strong>Nagasawa</strong>, H. T.; Goon, D. J. W.; Constantino, N. V.; Alexander, C. S. Diversion of<br />

Ethanol Metabolism by Sulfhydryl Amino Acids. D-Penicillamine-directed Excretion of<br />

2,5,5-Trimethyl-D-thiazolidine-4-carboxylic Acid in the Urine of Rats after Ethanol<br />

Administration. Life Sci. 1975, 17, 707-713.<br />

<strong>Nagasawa</strong>, H. T.; Kuo, T. H.; Shirota, F. N.; Alexander, C. S. An Intestinal Arylamidase<br />

that Selectively Hydrolyzes Certain Aromatic Amides. Biochem. Pharmacol. 1976, 25,<br />

855-858.<br />

Jenne, J. W.; <strong>Nagasawa</strong>, H. T.; Thompson, R. D. The Relationship of Urine Metabolites<br />

of Theophylline to Serum Theophylline Levels. Clin. Pharmacol. Ther. 1976, 19, 375-<br />

381.


Vince, R.; Almquist, R. G.; Ritter, C. L.; Shirota, F. N.; <strong>Nagasawa</strong>, H. T. An Active<br />

Puromycin Analog Derived from a Non-nephrotoxic Aminonucleoside. Life Sci. 1976,<br />

18, 345-350.<br />

Forsyth, G. W.; <strong>Nagasawa</strong>, H. T.; Alexander, C. S. Ethanol Metabolism by the Rat<br />

Heart and Alcohol Dehydrogenase Activity. Can. J. Biochem. 1976, 54, 539-545.<br />

Alexander, C. S.; Forsyth, G. W.; <strong>Nagasawa</strong>, H. T.; Kohloff, J. G. Alcoholic<br />

Cardiomyopathy in Mice. Myocardial Glycogen, Lipids and Certain Enzymes. J. Mol.<br />

Cell. Cardiol. 1977, 9, 235-245.<br />

Alexander, C. S.; Sekhri, K. K.; <strong>Nagasawa</strong>, H. T. Alcoholic Cardiomyopathy in Mice.<br />

Electron Microscopic Observations. J. Mol. Cell. Cardiol. 1977, 9, 247-254.<br />

<strong>Nagasawa</strong>, H. T.; Goon, D. J. W.; DeMaster, E. G.; Alexander, C. S. Lowering of<br />

Ethanol-Derived Circulating Blood Acetaldehyde in Rats by D-Penicillamine. Life Sci.<br />

1977, 20, 187-194.<br />

Goon, D. J. W.; <strong>Nagasawa</strong>, H. T. A Simple, Rapid and Semi-Automated Method for the<br />

Determination of Expired 14 CO2 in Metabolism Studies with Laboratory Animals. Res.<br />

Commun. Chem. Pathol. Pharmacol. 1977, 16, 745-748.<br />

Shirota, F. N.; <strong>Nagasawa</strong>, H. T.; Elberling, J. A. Potential Inhibitors of Collagen<br />

Biosynthesis. 4,4-Difluoro-L-proline and 4,4-Dimethyl-DL-proline and Their Activation<br />

by Prolyl-t-RNA Ligase. J. Med. Chem. 1977, 20, 1176-1181.<br />

DeMaster, E. G.; <strong>Nagasawa</strong>, H. T. Disulfiram-induced Acetonemia in the Rat and Man.<br />

Res. Commun. Chem. Pathol. Pharmacol. 1977, 18, 361-364.<br />

Shirota, F. N.; <strong>Nagasawa</strong>, H. T.; Elberling, J. A. Potential Inhibitors of Collagen<br />

Biosynthesis. 5.5-Difluorolysine and 5.5-Dimethyllysine and Their Activation by Lysyl-t-<br />

RNA Ligase. J. Med. Chem. 1977, 20, 1623-1627.<br />

<strong>Nagasawa</strong>, H. T.; Muldoon, W. P.; Shirota, F. N. Nitramino Acids. Synthesis and<br />

Biological Evaluation of 1-Nitroproline, 1-Nitropipecolic Acid and N-nitrosarcosine. J.<br />

Med. Chem. 1977, 20, 1588-1591.<br />

<strong>Nagasawa</strong>, H. T.; Alexander, C. S.; Goon, D. J. W.; DeMaster, E. G. Lowering of Blood<br />

Acetaldehyde Levels as a Therapeutic Approach to Alcoholism. In Alcohol and<br />

Aldehyde Metabolizing Systems, Vol. III; Thurman, R. G., Williamson, J. R., Pratt, H.,<br />

Chance, B., Eds.; Academic Press: New York, NY, 1978, pp 529-536.<br />

Alexander, C. S.; <strong>Nagasawa</strong>, H. T.; DeMaster, E. G. Lowering of Blood Acetaldehyde<br />

Levels--A Possible Approach to Prevention of Alcoholic Cardiomyopathy. In Recent<br />

Advances in Studies on Cardiac Structures and Metabolism, Vol. 12, Cardiac


Adaptation; Kobayashi, T.; Ito, Y.; Rona, G.; Eds.; University Park Press: Baltimore,<br />

MD, 1978, pp 345-350.<br />

DeMaster, E. G.; <strong>Nagasawa</strong>, H. T. Isoprene, an Endogenous Constituent of Human<br />

Alveolar Air with a Diurnal Pattern of Excretion. Life Sci. 1978, 22, 91-98.<br />

DeMaster, E. G.; <strong>Nagasawa</strong>, H. T. Inhibition of Aldehyde Dehydrogenase by<br />

Propiolaldehyde, a Possible Metabolite of Pargyline. Res. Commun. Chem. Pathol.<br />

Pharmacol. 1978, 21, 497-505.<br />

<strong>Nagasawa</strong>, H. T.; Goon, D. J. W.; DeMaster, E. G. 2, 5,5-Trimethylthiazolidine-4carboxylic<br />

Acid, a D(-)-Penicillamine-directed Pseudometabolite of Ethanol.<br />

Detoxication Mechanism for Acetaldehyde. J. Med. Chem. 1978, 21, 1274-1279.<br />

Elberling, J. A.; Zera, R. T.; Magnan, S. D. J.; <strong>Nagasawa</strong>, H. T. Phthaloyl-L-glutamic<br />

Anhydride (2-Phthalimidoglutaric Anhydride). Org. Prep. Proceed. Int. 1979, 11, 67-70.<br />

Shirota, F. N.; DeMaster, E. G.; <strong>Nagasawa</strong>, H. T. Propiolaldehyde, a Pargyline<br />

Metabolite that Irreversibly Inhibits Aldehyde Dehydrogenase. Isolation from a Hepatic<br />

Microsomal System. J. Med. Chem. 1979, 22, 463-464.<br />

<strong>Nagasawa</strong>, H. T.; Elberling, J. A.; DeMaster, E. G. Structural Requirements for the<br />

Sequestration of Metabolically-generated Acetaldehyde. J. Med. Chem. 1980, 23, 140-<br />

143.<br />

Shirota, F. N.; DeMaster, E. G.; Elberling, J. A.; <strong>Nagasawa</strong>, H. T. Metabolic<br />

Depropargylation and Its Relationship to Aldehyde Dehydrogenase Inhibition In Vivo. J.<br />

Med. Chem. 1980, 23, 669-673.<br />

<strong>Nagasawa</strong>, H. T.; Elberling, J. A.; Shirota, F. N. Latentiated Forms of the Transport<br />

Inhibitory -Amino Acid, Adamantanine. J. Pharm. Sci. 1980, 69, 1022-1025.<br />

DeMaster, E. G.; Shirota, F. N.; <strong>Nagasawa</strong>, H. T. Microsomal N-Depropargylation of<br />

Pargyline to Propiolaldehyde, an Irreversible Inhibitor of Mitochondrial Aldehyde<br />

Dehyddrogenase. In Alcohol and Aldehyde Metabolizing Systems, Vol. IV; Thurman, R.<br />

G., Ed.; Plenum Press, 1980, pp 219-228.<br />

Zera, R. T.; <strong>Nagasawa</strong>, H. T. N-Acetyl-DL-penicillamine and Acetominophen Toxicity in<br />

Mice. J. Pharm. Sci. 1980, 69, 1005-1006.<br />

Kaplan, E.; DeMaster, E. G.; <strong>Nagasawa</strong>, H. T. Effect of Pargyline on Hepatic<br />

Glutathione Levels in Rats Treated Acutely and Chronically with Ethanol. Res.<br />

Commun. Chem. Pathol. Pharmacol. 1980, 30, 577-580.<br />

<strong>Nagasawa</strong>, H. T.; Goon, D. J. W.; Shirota, F. N. Epimerization of C-2- of 2-Substituted<br />

Thiazolidine-4-carboxylic Acids. J. Heterocycl. Chem. 1981, 18, 1047-1051.


Zera, R. T.; <strong>Nagasawa</strong>, H. T. Inhibition of Paraldehyde Metabolism in Mice by SKF-<br />

525A. IRCS Med. Sci. 1981, 9, 988.<br />

Zera, R. T.; <strong>Nagasawa</strong>, H. T. Metabolism of Paraldehyde to Acetaldehyde by Rat Liver<br />

Microsome. Res. Commun. Chem. Pathol. Pharmacol. 1981, 34, 531-541.<br />

<strong>Nagasawa</strong>, H. T.; Magnan, S. D. J.; Foltz, R. L. Differentiation of - from -Glutamyl<br />

Dipeptides by Chemical Ionization Mass Spectrometry. Biomed. Mass Spectrom. 1982,<br />

9, 252-256.<br />

<strong>Nagasawa</strong>, H. T.; Goon, D. J. W.; Zera, R. T.; Yuzon, D. L. Prodrugs of L-Cysteine as<br />

Liver Protective Agents. 2(R,S)-Methylthiazolidine-4(R)-carboxylic Acid, a Latent<br />

Cysteine. J. Med. Chem. 1982, 25, 489-491.<br />

DeMaster, E. G.; <strong>Nagasawa</strong>, H. T. Effect of Phenobarbital Treatment on Pargylineinduced<br />

Acetaldehydemia after Ethanol in Sprague-Dawley and Fischer 344 Schf Rats.<br />

Res. Commun. Subs. Abuse 1982, 3, 211-217.<br />

Shirota, F. N.; DeMaster, E. G.; <strong>Nagasawa</strong>, H. T. Studies on the Cyanamide-Ethanol<br />

Interaction. Dimethylcyanamide as an Inhibitor of Aldehyde Dehydrogenase. Biochem.<br />

Pharmacol. 1982, 31, 1999-2004.<br />

Magnan, S. D. J.; Shirota, F. N.; <strong>Nagasawa</strong>, H. T. Drug Latentiation by gamma-<br />

Glutamyl-transpeptidase. J. Med. Chem. 1982, 25, 1018-1021.<br />

DeMaster, E. G.; Kaplan, E; Shirota, F. N.; <strong>Nagasawa</strong>, H. T. Metabolic Activation of<br />

Cyanamide by Liver Mitochondria: A Requirement for the Inhibition of Aldehyde<br />

Dehydrogenase Enzymes. Biochem. Biophys. Res. Commun. 1982, 107, 1333-1339.<br />

DeMaster, E. G.; Sumner, H. W.; Kaplan, E.; Shirota, F. N.; <strong>Nagasawa</strong>, H. T. Pargylineinduced<br />

Hepatoxicity. Possible Mediation by the Reactive Metabolite, propiolaldehyde.<br />

Toxicol. Appl. Pharmacol. 1982, 65, 390-401.<br />

DeMaster, E. G.; <strong>Nagasawa</strong>, H. T.; Shirota, F. N. Metabolic Activation of Cyanamide to<br />

an Inhibitor of Aldehyde Dehydrogenase In Vitro. Pharmacol. Biochem. Behav. 1983,<br />

18 (Suppl. 1), 273-278.<br />

Halberg, J.; DeMaster, E. G.; <strong>Nagasawa</strong>, H. T.; Halberg, F. Individualized and Group<br />

Circadian Rhythm and Corresponding Chronodems for Isoprene in Human Alveolar Air.<br />

Biochimica Clinica, 1983, 7, 905-914.<br />

DeMaster, E. G.; Shirota, F. N.; Redfern, B.; Goon, D. J. W.; <strong>Nagasawa</strong>, H. T. Analysis<br />

of Hepatic Reduced Glutathione, Cysteine, and Homocysteine, by Cation Exchange<br />

High Pressure Liquid Chromotography with Electrochemical Detection. J. Chromatogr.<br />

1984, 308, 83-91.


<strong>Nagasawa</strong>, H. T.; Goon, D. J. W.; Muldoon, W. P.; Zera, R. 2-Substituted Thiazolidine-<br />

4(R)-Carboxylic Acids as Prodrugs of L-Cysteine. Protection of Mice Against<br />

Acetaminophen Hepatotoxicity. J. Med. Chem., 1984, 27, 591-596.<br />

Shirota, F. N.; <strong>Nagasawa</strong>, H. T.; Kwon, C. H.; DeMaster, E. G. N-Acetylcyanamide, the<br />

Major Urinary Metabolite of Cyanamide in Rat, Rabbit, Dog and Man. Drug Metab.<br />

Dispos., 1984, 12, 337-344.<br />

<strong>Nagasawa</strong>, H. T.; Elberling, J. A.; DeMaster, E. G. Latent Inhibitors of Aldehyde<br />

Dehydrogenase as Alcohol Deterrent Agents. J. Med. Chem. 1984, 27, 1333-1339.<br />

DeMaster, E. G.; Shirota, F. N.; <strong>Nagasawa</strong>, H. T. The Metabolic Activation of<br />

Cyanamide to an Inhibitor of Aldehyde Dehydrogenase is Catalyzed by Catalase.<br />

Biochem. Biophys. Res. Commun. 1984, 122, 358-365.<br />

<strong>Nagasawa</strong>, H. T.; Smith, W. E.; Kwon, C. H.; Goon, D. J. W. Acetylative Cleavage of<br />

Arylsulfonylureas to N-Acetylarylsulfonamides and Isocyanates. J. Org. Chem. 1985,<br />

50, 4993-4996.<br />

DeMaster, E. G.; Shirota, F. N.; <strong>Nagasawa</strong>, H. T. Catalase Mediated Conversion of<br />

Cyanamide to an Inhibitor of Aldehyde Dehydrogenase. Alcohol 1985, 2, 117-121.<br />

<strong>Nagasawa</strong>, H. T.; DeMaster, E. G.; Kwon, C. H.; Fraser, P. S.; Shirota, F. N. Structure<br />

vs. Activity in the Sulfonylurea-Mediated Disulfiram-Ethanol Reaction. Alcohol 1985, 2,<br />

123-128.<br />

<strong>Nagasawa</strong>, H. T.; Kwon, C. H.; DeMaster, E. G.; Shirota, F. N. Prodrugs of Cyanamide<br />

as Long-Acting Alcohol Deterrent Agents. Biochem. Pharmacol. 1986, 35, 129-132.<br />

DeMaster, E. G.; Shirota, F. N.; <strong>Nagasawa</strong>, H. T. The Role of Propiolaldehyde and<br />

Other Metabolites in the Pargyline Inhibition of Rat Liver Aldehyde Dehydrogenase.<br />

Biochem. Pharmacol. 1986, 35, 1481-1489.<br />

DeMaster, E. G.; Redfern, B.; Shirota, F. N.; <strong>Nagasawa</strong>, H. T. Differential Inhibition of<br />

Rat Tissue Catalase by Cyanamide. Biochem. Pharmacol. 1986, 35, 2081-2085.<br />

Kwon, C. H.; <strong>Nagasawa</strong>, H. T.; DeMaster, E. G.; Shirota, F. N. Acyl, N-Protected alphaaminoacyl,<br />

and peptidyl Derivatives as Prodrug Forms of the Alcohol Deterrent Agent,<br />

Cyanamide. J. Med. Chem. 1986, 29, 1922-1929.<br />

Shirota, F. N.; DeMaster, E. G.; Kwon, C. H.; <strong>Nagasawa</strong>, H. T. Metabolism of<br />

cyanamide to cyanide and an inhibitor of aldehyde dehydrogenase (AlDH) by rat liver<br />

microsomes. Alcohol Alcoholism 1987, Suppl. 1, 219-223.


Shirota, F. N.; DeMaster, E. G.; <strong>Nagasawa</strong>, H. T. Cyanide is a Product of the Catalase<br />

Mediated Oxidation of the Alcohol Deterrent Agent, Cyanamide. Toxicol. Lett. 1987, 37,<br />

7-12.<br />

<strong>Nagasawa</strong>, H. T.; Elberling, J. A.; Roberts, J. C. ß-Substituted Cysteines as<br />

Sequestering Agents for Ethanol-Derived Acetaldehyde In Vivo. J. Med. Chem. 1987,<br />

30, 1373-1378.<br />

Kwon, C.-H.; <strong>Nagasawa</strong>, H. T. Facile Synthesis of 2-Iminohydantoins. Synth.<br />

Commun. 1987, 17, 1677-1682.<br />

Roberts, J. C.; <strong>Nagasawa</strong>, H. T.; Zera, R. T.; Fricke, R. F.; Goon, D. J. W. Prodrugs of<br />

L-cysteine as protective agents against acetaminophen-induced hepatotoxicity. 2-<br />

(Polyhydroxyalky)- and 2-(Polyacetoxyalkyl)-Thiazolidine-4(R)-Carboxylic Acids. J.<br />

Med. Chem. 1987, 30, 1891-1896.<br />

DeMaster, E. G.; Shirota, F. N.; <strong>Nagasawa</strong>, H. T. Oxidation of cyanamide by a cumene<br />

hydroperoxide supported catalase reaction yields cyanide and an inhibitor of aldehyde<br />

dehydrogenase. Biochem. Arch. 1988, 4, 203-207.<br />

Zieve, L.; <strong>Nagasawa</strong>, H. T. Methanethiols and Derivatives in Hepatic Failure. J. Lab.<br />

Clin. Med. 1988, 11 (Editorial), 595-597.<br />

<strong>Nagasawa</strong>, H. T.; Elberling, J. A.; Shirota, F. N.; DeMaster, E. G. A nonhypoglycemic<br />

Chlorpropamide Analog that Inhibits Aldehyde Dehydrogenase. Alcoholism Clin. Exp.<br />

Res. 1988, 12, 563-565.


Shirota, F. N.; <strong>Nagasawa</strong>, H. T. The Metabolism of the Alcohol Deterrent Agent,<br />

Cyanamide, is Not Altered by Acetylator Phenotype. In Biomedical and Social Aspects<br />

of Alcoholism; Kuriyama, K., Takada, A., Ishii, H., Eds.; Excerpta Medica: New York,<br />

1988; pp 127-130.<br />

<strong>Nagasawa</strong>, H. T.; Elberling, J. A.; DeMaster, E. G.; Shirota, F. N. N 1 -Alkyl Substituted<br />

Derivatives of Chlorprropamide as Inhibitors of Aldehyde Dehydrogenase. J. Med.<br />

Chem. 1989, 32, 1335-1340.<br />

Clark, C.; Woodson, M. M.; Winge, V. B.; <strong>Nagasawa</strong>, H. T. The Antiviral Drug<br />

Amantadine Has a Direct Inhibitory Effect on T-Lymphocytes. Immunopharmacol. 1989,<br />

18, 195-204.<br />

Goon, D. J. W.; Elberling, J. A.; DeMaster, E. G.; <strong>Nagasawa</strong>, H. T. Synthesis of [ 14 C]-<br />

Pargyline {N-Methyl-N-([1- 14 C]-propargyl)-benzylamine} with the Radioactive Label on<br />

the Propargyl Group. J. Label. Comp. Radiopharmaceuticals 1990, 18, 195-204.<br />

Kwon, C.-H.; <strong>Nagasawa</strong>, H. T. Intermolecular Decomposition Reactions of N-<br />

Acylcyanamides. J. Org. Chem. 1990, 55, 3403-3406.<br />

<strong>Nagasawa</strong>, H. T.; DeMaster, E. G.; Redfern, B.; Shirota, F. N.; Goon, D. J. W. Evidence<br />

for Nitroxyl in the Catalase-Mediated Bioactivation of the Alcohol Deterrent Agent,<br />

Cyanamide. J. Med. Chem. 1990, 33, 3120-3122.<br />

Clark, C.; Woodson, M. M.; <strong>Nagasawa</strong>, H. T. Inhibition of Lymphocyte Proliferation by<br />

Amantadine and its Isomer, 2-Aminoadamantane, Impact on Lyt-2+ T-cells while<br />

Sparing L3T4+ T-cells. Immunopharmacol. 1991, 21, 41-50.<br />

<strong>Nagasawa</strong>, H. T.; Kwon, C.-H.; Elberling, J. A.; Lee, M. J. C.; DeMaster, E. G.; Shirota,<br />

F. N.; Goon, D. J. W. Rationale for Alcoholism Treatment Based on Inhibition of<br />

Aldehyde Dehydrogenase. In Novel Pharmacological Interventions for Alcoholism;<br />

Naranjo, C.A., Sellers, E.M., Eds.; Springer-Verlag: New York, 1991, pp 247-250.<br />

Shirota, F. N.; Elberling, J. A.; <strong>Nagasawa</strong>, H. T.; DeMaster, E. G. Failure of Glutathione<br />

and Cysteine Prodrugs to Block the Chlorpropamide Induced Inhibition of Aldehyde<br />

Dehydrogenase in Rats. Biochem. Pharmacol. 1992, 43, 916-918.<br />

Roberts, J. C.; Charyulu, R. L.; Zera, R. T.; <strong>Nagasawa</strong>, H. T. Protection Against<br />

Acetaminophen Hepatotoxicity by the Glutathione Elevating Agent, Ribose-Cysteine<br />

(RibCys). Pharmacol. Toxicol. 1992, 70, 281-285.<br />

<strong>Nagasawa</strong>, H. T.; Lee, M. J. C.; Kwon, C.-H.; Shirota, F. N.; DeMaster, E. G. An N-<br />

Hydroxylated Derivative of Cyanamide that Inhibits Aldehyde Dehydrogenase. Alcohol<br />

1992, 9, 349-353.


Lee, M. J. C.; Elberling, J. A.; <strong>Nagasawa</strong>, H. T. N 1 -Hydroxylated Derivatives of<br />

Chlorpropamide and Its Analogs as Inhibitors of Aldehyde Dehydrogenase In Vivo. J.<br />

Med. Chem. 1992, 35, 3641-3647.<br />

Lee, M. J. C.; <strong>Nagasawa</strong>, H. T.; Elberling, J. A.; DeMaster, E. G. Prodrugs of Nitroxyl<br />

as Inhibitors of Aldehyde Dehydrogenase. J. Med. Chem. 1992, 35, 3648-3652.<br />

DeMaster, E.G.; Shirota, F.N.; <strong>Nagasawa</strong>, H.T. A Beckmann Type Dehydration of n-<br />

Butyaldoxime Catalyzed by Cytochrome P-450. J. Org. Chem. 1992, 57, 6074-6075.<br />

Fukuto, J. M.; Hszieh, R.; Gulati, P.; Chiang, K. T.; <strong>Nagasawa</strong>, H. T. N,O-Diacylated-Nhydroxyarylsulfonamides:<br />

Nitroxyl Precursors With Potent Smooth Muscle Relaxant<br />

Properties. Biochem. Biophys. Res. Commun. 1992, 137, 1367-1373.<br />

DeMaster, E. G.; Redfern, B.; Shirota, F. N.; Crankshaw, D. L.; <strong>Nagasawa</strong>, H. T.<br />

Metabolic Activation of n-Butyraldoxime by Rat Liver Microsomal Cytochrome P-450: A<br />

Requirement for the Inhibition of Aldehyde Dehydroqenase. Biochem. Pharmacol. 1993,<br />

46, 117-123.<br />

<strong>Nagasawa</strong>, H. T.; Yost, Y.; Elberling, J. A.; Shirota, F. N.; DeMaster, E. G. Nitroxyl<br />

Analogs as Inhibitors of Aldehyde Dehydrogenase. C-Nitroso Compounds. Biochem.<br />

Pharmacol. 1993, 45, 2129-2134.<br />

Fukuto, T. M.; Gulati, P.; <strong>Nagasawa</strong>, H. T. Involvement of Nitroxyl (HNO) in the<br />

Cyanamide-Induced Vasorelaxation of Rabbit Aorta. Biochem. Pharmacol. 1994, 47,<br />

922-924.<br />

Goon, D. J. W.; <strong>Nagasawa</strong>, H. T.; Keyler, D. E.; Ross, C. A.; Pentel, P. R. The<br />

Glutaramyl-β-Alanyl Spacer Group for Haptenic Coupling to Proteins. Preparation of<br />

Immunogens for Antibody Production Against Polychlorinated Biphenyls. Bioconj.<br />

Chem. 1994, 5, 418-422.<br />

Keyler, D. E.; Goon, D. J. W.; Shelver, W. L.; Ross, C. A.; <strong>Nagasawa</strong>, H. T.; Pentel, P.<br />

R. Redistribution and Enhanced Urinary Excretion of 2,2'4,4'5,5'-Hexachlorobiphenyl<br />

(HCB) in Rats Using HCB-Specific IgGand Fab Fragments. Biochem. Pharmacol. 1994,<br />

48, 767-773.<br />

<strong>Nagasawa</strong>, H. T.; Elberling, J. A.; Goon, D. J. W.; Shirota, F. N. Latent Isocyanates as<br />

Inhibitors of Aldehyde Dehydrogenase In Vivo. J. Med. Chem. 1994, 37, 422-426.<br />

<strong>Nagasawa</strong>, H. T.; Kawle, S. P.; Elberling, J. A.; DeMaster, E. G.; Fukuto, J. M.<br />

Prodrugs of Nitroxyl as Potential Aldehyde Dehydrogenase Inhibitors vis-a-vis Vascular<br />

Smooth Muscle Relaxants. J. Med. Chem. 1995, 38, 1865-1871.<br />

<strong>Nagasawa</strong>, H. T.; DeMaster, E. G.; Goon, D. J. W.; Kawle, S. P.; Shirota, F. N.<br />

Carbethoxylating Agents as Inhibitors of Aldehyde Dehydrogenase. J. Med. Chem.<br />

1995, 38, 1872-1876.


DeMaster, E. G.; Quast, B. J.; Redfern, B.; <strong>Nagasawa</strong>, H. T. Reaction of Nitric Oxide<br />

with the Free Sulfhydryl Group of Human Serum Albumin Yields a Sulfenic Acid and<br />

Nitrous Oxide. Biochemistry 1995, 34, 11494-11499.<br />

<strong>Nagasawa</strong>, H. T.; Cohen, J. F.; Rathbun, W. B. Mixed Disulfides of L-Cysteine and its<br />

Derivatives with 2-Mercapoethanol. Org. Prep. Proc. Int. 1996, 28, 237-241.<br />

Rathbun, W. B.; Killen, C. E.; Holleschau, A. M.; <strong>Nagasawa</strong>, H. T. Maintenance of<br />

Hepatic Homeostasis and Prevention of Acetaminophen-lnduced Cataracts in Mice by<br />

L-Cysteine Prodrugs. Biochem. Pharmacol. 1996, 51, 1111-1116.<br />

<strong>Nagasawa</strong>, H. T.; Cohen, J. F.; Holleschau, A. M.; Rathbun, W. B. Augmentation of<br />

Human and Rat Lenticular Glutathione in Vitro by Prodrugs of y-Glutamyl-L-Cysteine. J.<br />

Med. Chem. 1996, 39, 1676-1681.<br />

Rathbun, W. B.; Holleschau, A. M.; Cohen, J. F.; <strong>Nagasawa</strong>, H. T. Prevention of<br />

Acetaminophen and Naphthalene-Induced Cataract and Glutathione Loss by CYSSME.<br />

Invest. Ophthol. Vis. Sci. 1996, 37, 923-929.<br />

Rathbun, W. B.; <strong>Nagasawa</strong>, H. T.; Killen, C. E. Prevention of Naphthalene-Induced<br />

Cataract and Hepatic Glutathione Loss by the L-Cysteine Prodrugs, MTCA and PICA.<br />

Exp. Eye Res. 1996, 62, 433-441.<br />

Holleschau, A. M.; Rathbun, W. B.; <strong>Nagasawa</strong>, H. T. An HPLC Radiotracer Method for<br />

Assessing the Ability of L-Cysteine Prodrugs to Maintain Glutathione Levels in Cultured<br />

Rat Lens. Curr. Eye Res. 1996, 15, 501-510.<br />

Shirota, F. N.; Goon, D. J. W.; DeMaster, E. G.; <strong>Nagasawa</strong>, H. T. Nitrosyl Cyanide, a<br />

Putative Metabolic Oxidation Product of the Alcohol-Deterrent Agent Cyanamide.<br />

Biochem. Pharmacol. 1996, 52, 141-147.<br />

<strong>Nagasawa</strong>, H. T.; Shoeman, D. W.; Cohen, J. F.; Rathbun, W. B. Protection against<br />

Acetaminophen-lnduced Hepatotoxicity by L-CySSME and its N-Acetyl and Ethyl Ester<br />

Derivatives. J. Biochem. Toxicol. 1996, 11, 289-295.<br />

Shirota, F. N.; Stevens-Johnk, J. M.; DeMaster, E. G.; <strong>Nagasawa</strong>, H. T. Novel Prodrugs<br />

of Cyanamide that Inhibit Aldehyde Dehydrogenase in Vivo. J. Med. Chem. 1997, 40,<br />

1870.<br />

DeMaster, E. G.; Redfern, B.; Quasi, B. J.; Dahlseid, T.; <strong>Nagasawa</strong>, H. T. Mechanism<br />

for the Inhibition of Aldehyde Dehydrogenase by Nitric Oxide. Alcohol 1997, 14, 181-<br />

189.<br />

Deveraj, V. R.; Sreerama, L.; Lee, M. J. C.; <strong>Nagasawa</strong>, H. T., Sladek, N .E. Yeast<br />

Aldehyde Dehydrogenase Sensitivity to Inhibition by Chlorpropamide Analogues as an<br />

Indicator of Human Aldehyde Dehydrogenase to these Agents. Adv. Exp. Med. Biol.<br />

1997, 40, 1870-1875.


Bantseev, V.; Bhardwaj, R.; Rathbun, W.; <strong>Nagasawa</strong>, H.; Trevithick, J. R. Antioxidants<br />

and cataract: (cataract inductin in space environment and application to terrestrial aging<br />

cataract). Biochem. Mol. Biol. Int. 1997, 42, 1189-1197.<br />

Rekha, G. K.; Deveraj, V. R.; Sreerama, L.; Lee, M.J . C.; <strong>Nagasawa</strong>, H. T.; Sladek, N.<br />

E. Inhibition of Human Class 3 Aldehyde Dehydrogenase and Sensitization of Tumor<br />

Cells that Express Significant Amounts of this Enzyme to Oxazaphosphorines by<br />

Chlorpropamide Analogs. Biochem. Pharmacol. 1998, 55, 465-474.<br />

DeMaster, E. G.; Redfern, B.; <strong>Nagasawa</strong>, H. T. Mechanism of inhibition of aldehyde<br />

dehydrogenase by nitroxyl, the active metabolite of the alcohol deterrent agent<br />

cyanamide. Biochem. Pharmacol. 1998, 55, 2007-2015.<br />

Shoeman, D. W.; <strong>Nagasawa</strong>, H. T. The reaction of nitroxyl (HNO) with nitrosobenzene<br />

gives cupferon (N-nitrosophenylhydroxylamine). Nitric Oxide 1998, 2, 66-72.<br />

Conway, T. T.; DeMaster, E. G.; Lee, M. J. C.; <strong>Nagasawa</strong>, H. T. Prodrugs of nitroxyl<br />

and nitrosobenzene as cascade latentiated inhibitors of aldehyde dehydrogenase. J.<br />

Med. Chem. 1998, 41, 2903-2909.<br />

Wong, P. S.; Hyun J.; Fukuto, J. M.; Shirota, F. N.; DeMaster, E. G.; Shoeman, D. W.;<br />

<strong>Nagasawa</strong>, H. T. The reaction between S-nitrosothiols and thiols: Generation of nitroxyl<br />

and subsequent chemistry. Biochemistry 1998, 37, 5363-5371.<br />

King, S. B.; <strong>Nagasawa</strong>, H. T. Chemical approaches towards the generation of nitroxyl<br />

(HNO) in "Nitric Oxide". In Methods in Enzymology, vol. 301, part C: Biological and<br />

Antioxidant Activities. Lester Packer, Ed., Academic Press, New York, 1998, pp211-<br />

220.<br />

Wong, P.; Hyun, J.; Fukuto, J.; Shirota, F.; DeMaster, E.; <strong>Nagasawa</strong>, H. Chemical<br />

mechanisms involved in the reaction between S-nitrosothiols and thiols. The Biology of<br />

Nitric Oxide. Part 6,Vo\ 15; Moncada, S.; Toda, N.; Maeda, H.; Higgs, E. A., Eds.;<br />

Portland Press Proc., 1998, p 310.<br />

Conway, T. T.; DeMaster, E. G.; Goon, D. J. W.; Shirota, F. N.; <strong>Nagasawa</strong>, H. T.<br />

Diethyl-carbamoylating/nitroxylating agents as dual action inhibitors of aldehyde<br />

dehydro-genase. A disulfiram-cyanamide merger. J. Med. Chem. 1999, 42, 4016-4020.<br />

<strong>Nagasawa</strong>, H. T.; Shirota, F. N.; DeMaster, E. G . Alcoholism: Aldehyde<br />

Dehydrogenase Inhibitors as Alcohol Deterrent Agents. Biomedical Chemistry/Applying<br />

Chemical Principles to the Understanding andTreatment of Disease 1999, 73-79.<br />

Shirota, F. N.; DeMaster, E. G.; Lee, M. J. C.; <strong>Nagasawa</strong>, H. T. Generation of nitric<br />

oxide (NO) and possibly nitroxyl (HNO), respectively, by nitrosation of sulfohydroxamic<br />

acids and hydroxamic acids. Nitric Oxide 1999, 3, 445-453.


Elberembally, K.; <strong>Nagasawa</strong>, H. T. 2-Alkoxy-1,2-benzothiazin-3(3H)one 1,1-dioxides as<br />

potential prodrugs of nitroxyl. Sulfur Lett. 1999, 23, 57-65.<br />

Shoeman, D. W.; Shirota, F. N.; DeMaster, E. G.; <strong>Nagasawa</strong>, H. T. Reaction of nitroxyl<br />

(HNO), a putative inhibitor of aldehyde dehydrogenase, with N-acetyl-L-cysteine.<br />

Alcohol 2000, 20, 55-59.<br />

Cohen, J. F.; Elberling, J A.; DeMaster, E. G.; Lin, R. C.; <strong>Nagasawa</strong>, H. T. N-Terminal<br />

dipeptides of D(-)-Penicillamine as sequestration agents for acetaldehyde. J. Med,<br />

Chem. 2000, 43, 1029-1033.<br />

Chen, T. S.; Richie Jr., J. P.; <strong>Nagasawa</strong>, H. T.; Lang, C. A. Glutathione monoethyl ester<br />

protects against glutathione deficiencies due to aging and acetaminophen in mice.<br />

Mechanisms of Ageing and Development 2000, 120, 127-139.<br />

Sladek, N. E.; Rekha, G. K.; Lee, M. J. C.; <strong>Nagasawa</strong>, H. T. Inhibition of ALDH3A1catalyzed<br />

oxidation by chlorpropamide analogues. Chem-Biol. Int. 2001, 130-132, 135-<br />

149.<br />

Srinivasan, C.; Williams, W. M.; <strong>Nagasawa</strong>, H. T.; Chen, T. S. Effects of 2(RS)-npropylthiazolidine-4(R)-carboxylic<br />

acid on extrahepatic sulfhydryl levels in mice treated<br />

with acetaminophen. Biochem. Pharmacol. 2001, 61, 925-931.<br />

Lee, M. J. C.; Shoeman, D. W.; Goon, D. J. W.; <strong>Nagasawa</strong>, H. T. N-<br />

Hydroxybenzenecarboximidic acid derivatives: A new class of nitroxyl-generating<br />

prodrugs. Nitric Oxide 2001, 5, 278-287.<br />

Shirota, F. N.; DeMaster, E. G.; Shoeman, D. W.; <strong>Nagasawa</strong>, H. T. Acetaminopheninduced<br />

suppression of hepatic AdoMet synthetase is attenuated by prodrugs of Lcysteine.<br />

Toxicol. Lett. 2002, 132, 1-8.<br />

Crankshaw, D. L.; Berkeley, L. I.; Cohen, J. F.; Shirota, F. N.; <strong>Nagasawa</strong>, H. T. Doubleprodrugs<br />

of L-cysteine: Differential protection against acetaminophen-induced<br />

hepatotoxicity in mice. J. Biochem. Mol. Toxicol. 2002, 16, 235-244.<br />

Berkeley, L. I.; Cohen, J. F.; Crankshaw, D. L.; Shirota, F. N.; <strong>Nagasawa</strong>, H. T.<br />

Hepatoprotection by L-cysteine-glutathione mixed disulfide, a sulfhydryl-modified<br />

prodrug of glutathione. J. Biochem. Mol. Toxicol. 2003, 17, 95-97.<br />

Fu, X.; Chen, T. S.; Ray, M. B.; <strong>Nagasawa</strong>, H. T.; Williams, W. M. p-Aminphenolinduced<br />

hepatotoxicity in hamsters: role of glutathione. J. Biochem. Mol. Toxicol. 2004,<br />

18, 154-161.<br />

<strong>Nagasawa</strong>, H. T.; Cummings, S. E.; Baskin, S. I. The structure of "ITCA", a urinary<br />

metabolite of cyanide. Prep. Proced. Internat. Briefs 2004, 36, 178-182.


Oz, H. S.; McClain, C. J.; Ray, M. B.; <strong>Nagasawa</strong>, H. T.; Chen, T. S. Diverse antioxidants<br />

protect against acetaminophen heptotoxicity. J. Biochem. Mol. Toxicol. 2004, 18, 361-<br />

368.<br />

Phimister, A. J.; <strong>Nagasawa</strong>, H. T.; Buckpitt, A. R.; Plopper, C. G. Prevention of<br />

naphthalene induced pulmonary toxicity by glutathione prodrugs: roles for glutathione<br />

depletion in adduct formation and cell injury. J. Biochem. Mol. Toxicol. 2005, 19,, 42-52.<br />

Miranda, K. M.; <strong>Nagasawa</strong>, H. T.; Toscano, J. P. Donors of HNO. Current Topics in<br />

Medicinal Chemistry 2005, 5, 649-664.<br />

Oz, H.S.; Chen, C. S.; <strong>Nagasawa</strong>, H. T. Comparative efficacies of two cysteine<br />

prodrugs and a glutathione delivery agent in a colitis model. Translational Res. 2007,<br />

150, 122-129.


Patents:<br />

<strong>Nagasawa</strong>, H. T.; Kwon, C.-H. Acylated Cyanamide Composition for Treating Ethanol<br />

Ingestion. United States Patent No. 4,726,941, Feb. 23, 1988.<br />

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