changes in protein profiles in bortezomib applied multiple myeloma ...
changes in protein profiles in bortezomib applied multiple myeloma ...
changes in protein profiles in bortezomib applied multiple myeloma ...
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Figure 1.2. Development of Cancer<br />
Six considerable characteristics found <strong>in</strong> cancer cells are called hallmarks of<br />
cancer (Hanahan and We<strong>in</strong>berg, 2000). They are as follows :<br />
Self-sufficiency <strong>in</strong> growth signals,<br />
Insensitivity to antigrowth signals,<br />
Evasion of apoptosis,<br />
Limitless replicative potential,<br />
Susta<strong>in</strong>ed angiogenesis,<br />
Tissue <strong>in</strong>vasion and metastasis.<br />
1.2. Multiple Myeloma (MM)<br />
Multiple Myeloma (MM) (also known as <strong>myeloma</strong>tosis, plasma cell <strong>myeloma</strong><br />
or Kahler's disease) is a malignant B-cell neoplasm that is characterized by the<br />
accumulation of malignant plasma cells <strong>in</strong> the bone marrow. It is known as bone<br />
marrow cancer <strong>in</strong> the society and it is the second most common hematological disorder<br />
(Raab et al., 2009). It accounts for 2% of cancer deaths among the most dangerous<br />
cancer types (Zaidi and Vesole, 2001). Recently, <strong>in</strong>creas<strong>in</strong>g number of people is be<strong>in</strong>g<br />
diagnosed as MM. It has a yearly <strong>in</strong>cidence of nearly 14-15 thousand that accounts for<br />
approximately 10% of all hematologic cancers <strong>in</strong> the US (San et al., 1999; Coll<strong>in</strong>s,<br />
4