PHS 398/2590 (Rev. 06/09) - Jules Stein Eye Institute
PHS 398/2590 (Rev. 06/09) - Jules Stein Eye Institute
PHS 398/2590 (Rev. 06/09) - Jules Stein Eye Institute
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NAME<br />
Sun, Hui<br />
EDUCATION/TRAINING<br />
INSTITUTION AND LOCATION<br />
BIOGRAPHICAL SKETCH<br />
Page 1<br />
POSITION TITLE<br />
Associate Professor of Physiology<br />
and Ophthalmology<br />
DEGREE<br />
(if applicable)<br />
YEAR(S) FIELD OF STUDY<br />
Johns Hopkins University PhD 1992-1998 Biochemistry & Mol. Bio.<br />
Johns Hopkins University Postdoc 1998-1999 Biochemistry<br />
Kennedy Krieger <strong>Institute</strong> N/A 2002-2003 Animal Model<br />
Cold Spring Harbor Laboratory N/A 2002 Animal Model<br />
Howard Hughes Medical <strong>Institute</strong><br />
Postdoc 1999-2003 Biochemistry<br />
A. Positions and Honors:<br />
Positions<br />
2003-20<strong>09</strong> Assistant Professor, Department of Physiology and Department of Ophthalmology, David<br />
Geffen School of Medicine, University of California, Los Angeles<br />
2004-present Associate Member, <strong>Jules</strong> <strong>Stein</strong> <strong>Eye</strong> <strong>Institute</strong>, David Geffen School of Medicine, University of<br />
California, Los Angeles<br />
2003-present Member, Brain Research <strong>Institute</strong>, University of California, Los Angeles<br />
20<strong>09</strong>-present Associate Professor, Department of Physiology and Department of Ophthalmology, David<br />
Geffen School of Medicine, University of California, Los Angeles<br />
20<strong>09</strong>-present Early Career Scientist, Howard Hughes Medical <strong>Institute</strong><br />
Honors<br />
1998 Alicia Showalter Reynolds Prize, Johns Hopkins University<br />
2003 Karl Kirchgessner Foundation Award<br />
2004 <strong>Stein</strong>-Oppenheimer Endowment Award, University of California, Los Angeles<br />
2004 Ruth and Milton <strong>Stein</strong>bach Award<br />
2005 E. Matilda Ziegler Foundation Award<br />
20<strong>06</strong> Ellison Medical Foundation New Scholar<br />
20<strong>09</strong> Howard Hughes Medical <strong>Institute</strong> Early Career Scientist<br />
B. Teaching Activities:<br />
2010: MCIP 215, Molecular and Cellular Foundation of Physiology, University of California, Los<br />
Angeles, Graduate School<br />
2010: System 2, Gastrointestinal Physiology, University of California, Los Angeles, School of<br />
Dentistry<br />
20<strong>09</strong>: Problem Based Learning, Foundation of Medicine, University of California, Los Angeles,<br />
School of Medicine<br />
20<strong>09</strong>: System 2, Gastrointestinal Physiology, University of California, Los Angeles, School of<br />
Dentistry<br />
2008: Problem Based Learning, Foundation of Medicine, University of California, Los Angeles,<br />
School of Medicine<br />
2008: Physiology 100, Gastrointestinal Physiology, University of California, Los Angeles, School of<br />
Dentistry
2007: Problem Based Learning, Foundation of Medicine, University of California, Los Angeles,<br />
School of Medicine<br />
2007: Physiology 100, Gastrointestinal Physiology, University of California, Los Angeles, School of<br />
Dentistry<br />
20<strong>06</strong>: Problem Based Learning, Foundation of Medicine, University of California, Los Angeles,<br />
School of Medicine<br />
20<strong>06</strong>: Physiology 100, Gastrointestinal Physiology, University of California, Los Angeles, School of<br />
Dentistry<br />
2005: M205, The Retina, Systems Neuroscience, University of California, Los Angeles, Graduate<br />
School<br />
2005: CM 267B, Cell Structure, Signaling, and Differentiation, University of California, Los Angeles,<br />
Graduate School<br />
2004: Physiology 100, Gastrointestinal Physiology, University of California, Los Angeles, School of<br />
Dentistry<br />
C. Selected Publications:<br />
1. Allikmets, R., Singh, N., Sun, H., Shroyer, N.F., Hutchinson, A, Chidambaram, A., Gerrard, B., Baird,<br />
L., Stauffer, D., Peiffer, A., Rattner, A., Smallwood, P., Li, Y., Anderson, K.L., Lewis, R.A., Nathans, J.,<br />
Leppert, M., Dean, M., and Lupski, J.R. A photoreceptor cell-specific ATP-binding transporter gene<br />
(ABCR) is mutated in recessive Stargardt macular dystrophy. Nature Genetics 15, 236-246 (1997).<br />
2. Sun, H., Macke, J.P., and Nathans, J. Mechanisms of spectral tuning in the mouse green cone<br />
pigment. Proc. Natl. Acad. Sci. USA 94, 8860-8865 (1997).<br />
Free Access: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC23167/?tool=pubmed<br />
3. Sun, H., Gilbert, D.J., Copeland, N.G., Jenkins, N.A., and Nathans, J. Peropsin, a novel visual<br />
pigment-like protein located in the apical microvilli of the retinal pigment epithelium. Proc. Natl. Acad.<br />
Sci. USA 94, 9893-9898 (1997).<br />
Free Access: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC23288/?tool=pubmed<br />
4. Sun, H., and Nathans, J. Stargardt's ABCR is localized to the disc membrane of retinal rod outer<br />
segments. Nature Genetics 17, 15-16 (1997).<br />
5. Sun, H., Molday, R.S., and Nathans, J. Retinal stimulates ATP hydrolysis by purified and<br />
reconstituted ABCR, the photoreceptor-specific ATP-binding cassette transporter responsible for<br />
Stargardt disease. J. Biol. Chem. 274: 8269-8281 (1999).<br />
Free Access: http://www.jbc.org/content/274/12/8269.long<br />
6. Sun, H., Smallwood, P.M., and Nathans, J. Biochemical defects in ABCR protein variants associated<br />
with human retinopathies. Nature Genetics 26, 242-246 (2000).<br />
7. Sun, H., and Nathans, J. ABCR, the ATP-binding cassette transporter responsible for Stargardt<br />
macular dystrophy, is an efficient target of all-trans-retinal-mediated photooxidative damage in vitro:<br />
implications for retinal disease. J. Biol. Chem. 276,11766-11774 (2001).<br />
Free Access: http://www.jbc.org/content/276/15/11766.long<br />
8. Sun, H., and Nathans, J. Mechanistic studies of ABCR, the ABC transporter in photoreceptor outer<br />
segments responsible for autosomal recessive Stargardt disease. J Bioenerg Biomembr. 33, 519-<br />
526 (2001).<br />
9. Sun, H., Tsunenari, T., Yau, K.W., and Nathans, J., The vitelliform macular dystrophy protein defines<br />
a new family of chloride channels. Proc. Natl. Acad. Sci. USA 99, 4008-4013 (2002).<br />
Free Access: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC122639/?tool=pubmed<br />
10. Jin, M., Li, S., Moghrabi, W.N., Sun, H., and Travis, G.H. RPE65 is the retinoid isomerase in bovine<br />
retinal pigment epithelium. Cell 122:449-459 (2005).<br />
Free Access: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2748856/?tool=pubmed<br />
11. Yang, Z., Camp, N., Sun, H., Tong, Z., Gibbs, D., Cameron, J., Chen, H., Zhao, Y., Pearson, E., Li, X.,<br />
Chien, J., DeWan, A., Harmon, J., Bernstein, P., Shridhar, V., Zabriskie, N., Hoh, J., Howes, K., and<br />
Zhang, K. A variant of the HTRA1 gene increases susceptibility to age-related macular degeneration.<br />
Science 314: 992-993 (20<strong>06</strong>).<br />
Page 2
12. Kawaguchi, R., Yu, J., Honda, J., Hu, J., Whitelegge, J., Ping, P., Wiita, P., Bok, D., and Sun, H. A<br />
membrane receptor for retinol binding protein mediates cellular uptake of vitamin A. Science<br />
(Research Article) 315: 820-825 (2007).<br />
This article was highlighted in the following scientific news:<br />
Science News, Science January 25, 2007<br />
Research Highlights, Nature 445: 462, 2007<br />
Research Highlights, Nature Chemical Biology 3:143, 2007<br />
Editor’s Choice, Science STKE 373:55, 2007<br />
Research Spotlight, ACS Chemical Biology 2:142, 2007<br />
This week in Science, Science 315: 735, 2007<br />
Research News, The Scientist, January 25, 2007<br />
Rated as “Exceptional” by Faculty of 1000 Biology<br />
13. Yu, J., Wiita, P., Kawaguchi, R., Honda, J., Jorgensen, A., Zhang, K., Fishchetti, V., and Sun, H.<br />
Biochemical analysis of a common human polymorphism associated with age-related macular<br />
degeneration. Biochemistry 46:8451-8461 (2007).<br />
14. Kawaguchi, R., Yu, J., Wiita, P., Ter-Stepanian, M., and Sun, H. Mapping the Membrane Topology<br />
and Extracellular Ligand Binding Domains of the Retinol Binding Protein Receptor. Biochemistry 47:<br />
5387-5395 (2008).<br />
15. Kawaguchi, R., Yu, J., Wiita, P., Honda, J., and Sun, H. An Essential Ligand Binding Domain in the<br />
Membrane Receptor for Retinol Binding Protein <strong>Rev</strong>ealed by Large-Scale Mutagenesis and a Human<br />
Polymorphism. J. Biol. Chem. 283:15160-15168 (2008).<br />
Free Access: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2397481/?tool=pubmed<br />
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