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A. Zipper mechanism<br />
Invasin<br />
Yersinia<br />
Invasin medi<strong>at</strong>ed entry<br />
FAK<br />
β β<br />
integrins<br />
Microtubules<br />
Invasin<br />
B. Trigger mechanism<br />
A<br />
Salmonella<br />
Cdc42/Rac<br />
SopB<br />
IP5 IP4<br />
Src<br />
Rac<br />
N-WASP<br />
B B<br />
C C<br />
SopE SptP<br />
GEF<br />
FAK<br />
Cdc42/Rac<br />
Internalin medi<strong>at</strong>ed entry<br />
E-cadherin<br />
Myo<br />
PIP2<br />
IpgD<br />
PIP<br />
InlA<br />
Cortactin<br />
P<br />
InlA<br />
β β<br />
α<br />
α<br />
C<strong>at</strong>enins<br />
Rac<br />
WSP<br />
Cdc42/Rac<br />
x Sip/Ipa proteins<br />
GAP<br />
WSP WASP family protein<br />
E-cadherin<br />
<strong>Shigella</strong><br />
B<br />
C<br />
VirA<br />
Vez<strong>at</strong>in<br />
Myo<br />
B C<br />
Src<br />
Listeria<br />
P P<br />
Vinculin<br />
A<br />
Rho<br />
p190GAP<br />
Microtubules<br />
InlB (bacterial<br />
<strong>at</strong>tached or free)<br />
VASP<br />
P<br />
Met<br />
Rac<br />
WAVE<br />
InlB medi<strong>at</strong>ed entry<br />
=<br />
P<br />
LIM-K<br />
InlB<br />
Cbl<br />
Gab1<br />
Shc<br />
P<br />
P<br />
P<br />
PIP2<br />
PI3K<br />
Cofilin<br />
PIP3<br />
Type III secretion<br />
appar<strong>at</strong>us<br />
Actin<br />
Arp2/3 complex<br />
Rho GTPases<br />
Bacterial proteins<br />
VASP<br />
Cossart & Sansonetti,Science, 2004
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