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OspD1<br />
MxiE<br />
« First wave » of<br />
effectors expressed<br />
<strong>at</strong> 37°C prior to<br />
activ<strong>at</strong>ion of TTSS<br />
OspD1<br />
IpaA<br />
virF virB<br />
37°C<br />
ipaBCDA-ipg(s) ipg(s)-mxi - spa (mxiE)<br />
IpaB IpgC<br />
IpaD<br />
IpaD<br />
IpaD<br />
IpaC<br />
virF virB<br />
37°C<br />
IpgC<br />
osp(s)-ipaH(s)<br />
Spa15<br />
IpaA<br />
IpgE<br />
IpgD<br />
osp(s)-ipaH(s)-virA<br />
OspD1<br />
MxiE<br />
ipaBCDA-ipg(s) ipg(s)-mxi - spa (mxiE)<br />
IpaB<br />
IpaD IpaD<br />
IpaD<br />
IpaC<br />
IpgD IpgD<br />
IpaA IpaA<br />
IpaD<br />
MxiE MxiE<br />
MxiE<br />
MxiE<br />
IpgC<br />
IpgC<br />
IpaD<br />
MxiE<br />
IpaB IpaB<br />
<strong>Shigella</strong><br />
IpaD IpaD<br />
IpaD<br />
IpaD IpaD<br />
Inactive TTSS in<br />
absence of<br />
cellular target<br />
IIpaC IIpaC<br />
IpgC<br />
Activ<strong>at</strong>ed TTSS in<br />
presence of<br />
cellular target<br />
IpgD<br />
OspD1<br />
Buchrieser et al., 1998, Mol.Microbiol.
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