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Shigella Effectors at Work - EMBO

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Xenotransplant<strong>at</strong>ion of human fetal intestine<br />

subcutaneously in SCID mice<br />

Mouse<br />

mice Collabor<strong>at</strong>ion with Samuel Stanley<br />

(Washington University, University,<br />

St Louis)<br />

Human<br />

Target genes of the MxiE-dependent<br />

effectors<br />

Chemokines & chemokine receptors:<br />

CCL3, CCL4, CCL20, CCL25,<br />

CCRL2<br />

Cytokines and cytokine receptors:<br />

IL-7, IL-18, IL-13RA1, IL-20RA<br />

Antimicrobial peptides:<br />

HBD1, HBD3

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