Shigella Effectors at Work - EMBO
Shigella Effectors at Work - EMBO Shigella Effectors at Work - EMBO
Participitation of membrane remnants in NF-κB response to pathogen invasion in MEF cells (autophagy-dependent modulation of the inflammatory response) Increase of NF-κB activation Membrane remnants: pro-inflammatory signaling platform upon Shigella invasion. 2H
37°C Contact virF virB ipaC ipaB ipgC mxi-spa mxiE ipaHs ospBCDEFG IpaC IpgC IpaB IpgC virF virB MxiE OspD1 TTSS ipaC ipaB ipgC mxi-spa mxiE ipaHs ospBCDEFG IpaC IpgC IpaB MxiE MxiE IpgC IpgCOspD1 OspD1 IpgC IpaC IpaB MxiE OspD1 IpaH IpaH Osp Osp ? Regulatory cascade controling transcription of ipaH & osp genes in response to two external signals: (1) temperature (2) TTSS activation The mxiE regulon AraC-family transcription activator: MxiE Anti-activator: OspD1 Coactivator: IpgC Anti-coactivators: IpaB, IpaC Parsot C, Demers B, Mavris M, Penno C, Bongrand C et al.
- Page 1 and 2: Shigella effectors at work Invasion
- Page 3 and 4: HISTOPATHOLOGY OF SHIGELLOSIS ELEME
- Page 5 and 6: The Shigella invasion pathogenicity
- Page 7 and 8: Posters of the III rd type: Marlise
- Page 9 and 10: A. Zipper mechanism Invasin Yersini
- Page 11 and 12: Alto et al. Ohya et al. IpgB ELMO/D
- Page 13 and 14: IpaC last 72 aa fused to iota Ia co
- Page 15 and 16: Rupture, invasion and inflammatory
- Page 17 and 18: Adaptation of Shigella to the gut e
- Page 19 and 20: GlcNAc O O CH O HCCH 3 CO CO CH 3 L
- Page 21: cytokines chemokines Inhibition of
37°C<br />
Contact<br />
virF virB<br />
ipaC ipaB ipgC mxi-spa mxiE ipaHs ospBCDEFG<br />
IpaC<br />
IpgC<br />
IpaB<br />
IpgC<br />
virF virB<br />
MxiE<br />
OspD1<br />
TTSS<br />
ipaC ipaB ipgC mxi-spa mxiE ipaHs ospBCDEFG<br />
IpaC<br />
IpgC<br />
IpaB<br />
MxiE MxiE<br />
IpgC IpgCOspD1<br />
OspD1 IpgC<br />
IpaC IpaB<br />
MxiE<br />
OspD1<br />
IpaH<br />
IpaH<br />
Osp<br />
Osp<br />
?<br />
Regul<strong>at</strong>ory cascade controling<br />
transcription of ipaH & osp genes<br />
in response to two external signals:<br />
(1) temper<strong>at</strong>ure<br />
(2) TTSS activ<strong>at</strong>ion<br />
The mxiE regulon<br />
AraC-family transcription<br />
activ<strong>at</strong>or: MxiE<br />
Anti-activ<strong>at</strong>or: OspD1<br />
Coactiv<strong>at</strong>or: IpgC<br />
Anti-coactiv<strong>at</strong>ors: IpaB, IpaC<br />
Parsot C, Demers B, Mavris M,<br />
Penno C, Bongrand C et al.
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