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Antimicrobial<br />
molecules<br />
COMMENSALS<br />
Absence (limit<strong>at</strong>ion) of virulence factors<br />
PAMPs less agonist ?<br />
Sequestr<strong>at</strong>ion, weak activity of TLRs<br />
Life in biofilms on mucus surface<br />
Controled diffusion and sampling of PAMPs<br />
And prokaryotic signalis<strong>at</strong>ion molecules<br />
TLR<br />
QSM MDP<br />
OCTN2 PepT1<br />
?<br />
Regul<strong>at</strong>ory<br />
cascade<br />
NLR<br />
Regul<strong>at</strong>ory genes<br />
Regul<strong>at</strong>ory cytokines, chemokines<br />
Mucus<br />
Imm<strong>at</strong>ure DC & MΦ M<br />
Treg<br />
DC<br />
PATHOGENS<br />
Mucinases<br />
Adhesins / Invasins<br />
Type III / IV secretory systems<br />
Hemolysins<br />
Massive engagement of TLRs, NLRs<br />
Eradic<strong>at</strong>ion of commensal fmicrobiota (niche occupancy)<br />
+ Dampening inn<strong>at</strong>e / inflamm<strong>at</strong>ory responses<br />
TLR<br />
PMN<br />
Pro-inflamm<strong>at</strong>ory<br />
cascade<br />
NLR<br />
Pro-inflamm<strong>at</strong>ory Pro-inflamm<strong>at</strong>ory<br />
genes<br />
Pro-inflamm<strong>at</strong>ory<br />
Pro-inflamm<strong>at</strong>ory<br />
cytokines, chemokines<br />
Activ<strong>at</strong>ed DC & MΦ M<br />
Th1 / Th17<br />
PMN
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