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<strong>Shigella</strong> life style <strong>at</strong> mucosal surface - Sign<strong>at</strong>ure Tagged Mutagenesis<br />
2900 STM mutants<br />
screened vs M90T/wt in<br />
the rabbit lig<strong>at</strong>ed intestinal<br />
loop model<br />
15 severely defective mutants identified...<br />
- 7 LPS-biogenesis mutants<br />
West et al., Science, 2005<br />
- fnr : virulence of <strong>Shigella</strong> rel<strong>at</strong>ed to oxygen<br />
tension<br />
Strain<br />
M90TDfnr<br />
M90TDfnr pBM2<br />
BS176<br />
Competitive<br />
Index (C.I.)<br />
0.05<br />
0.6<br />
0.8<br />
Rabbit ileal loop model<br />
18 hours infection<br />
M90TDfnr pBM2<br />
INPUT<br />
M90T M90TDfnr<br />
M90TDmxiD<br />
OUTPUT<br />
Marteyn et al., N<strong>at</strong>ure, 2010
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