Shigella Effectors at Work - EMBO
Shigella Effectors at Work - EMBO Shigella Effectors at Work - EMBO
Bernardini et al., PNAS, 1989 IcsA Glycin-rich repeats Activation of N-WASP 3 G-actin 2 3 2 Arp2/3complex Capping protein F-actin Activation of Arp2/3 complex 3 3 α-actinin 2 2 3 2 Tread milling ADF/Profilin IcsA vacuole lysis (TTSS) epithelial cells basolateral macropinocytosis (TTSS) mucus motility cell to cell spread (TTSS)
Rupture, invasion and inflammatory destruction of the intestinal epithelium by Shigella: the key steps of TTSS function. TTSS PGN IL-8, other cytokines chemokines Nod1 NF-κB JNK Pro-inflammatory genes 3 Defensins and other bactericidal molecules PNN - Development of inflammation - Rupture of epithelial barrier - Facilitation of invasion - Stimulation of epithelial bactericidal capacities CCL-20 DC Follicle-associated epithelium M cell MΦ 1 2 Lympho B MΦ pyroptosis TTSS/IpaB «facilitated translocation» IcsA ? - Activation of caspase-1 - Pyroptosis = proinflammatory apoptosis - Release of IL-1β and IL-18 ? Vacuole lysis (TTSS) Escape to autophagy initiation of inflammation subepithelial release of bacteria mucus Motility, cell to cell spread (TTSS) Epithelial cells Basolateral macropinocytosis (TTSS)
- Page 1 and 2: Shigella effectors at work Invasion
- Page 3 and 4: HISTOPATHOLOGY OF SHIGELLOSIS ELEME
- Page 5 and 6: The Shigella invasion pathogenicity
- Page 7 and 8: Posters of the III rd type: Marlise
- Page 9 and 10: A. Zipper mechanism Invasin Yersini
- Page 11 and 12: Alto et al. Ohya et al. IpgB ELMO/D
- Page 13: IpaC last 72 aa fused to iota Ia co
- Page 17 and 18: Adaptation of Shigella to the gut e
- Page 19 and 20: GlcNAc O O CH O HCCH 3 CO CO CH 3 L
- Page 21 and 22: cytokines chemokines Inhibition of
- Page 23 and 24: 37°C Contact virF virB ipaC ipaB i
Rupture, invasion and inflamm<strong>at</strong>ory destruction of the intestinal<br />
epithelium by <strong>Shigella</strong>: the key steps of TTSS function.<br />
TTSS<br />
PGN<br />
IL-8, other cytokines<br />
chemokines<br />
Nod1<br />
NF-κB<br />
JNK<br />
Pro-inflamm<strong>at</strong>ory<br />
genes<br />
3<br />
Defensins and other bactericidal<br />
molecules<br />
PNN<br />
- Development of inflamm<strong>at</strong>ion<br />
- Rupture of epithelial barrier<br />
- Facilit<strong>at</strong>ion of invasion<br />
- Stimul<strong>at</strong>ion of epithelial bactericidal<br />
capacities<br />
CCL-20<br />
DC<br />
Follicle-associ<strong>at</strong>ed epithelium<br />
M cell<br />
MΦ<br />
1 2<br />
Lympho B<br />
MΦ<br />
pyroptosis<br />
TTSS/IpaB<br />
«facilit<strong>at</strong>ed<br />
transloc<strong>at</strong>ion»<br />
IcsA<br />
?<br />
- Activ<strong>at</strong>ion of caspase-1<br />
- Pyroptosis = proinflamm<strong>at</strong>ory<br />
apoptosis<br />
- Release of IL-1β and IL-18<br />
?<br />
Vacuole lysis<br />
(TTSS)<br />
Escape to<br />
autophagy<br />
initi<strong>at</strong>ion of inflamm<strong>at</strong>ion subepithelial release of bacteria<br />
mucus<br />
Motility, cell to cell<br />
spread (TTSS)<br />
Epithelial cells<br />
Basol<strong>at</strong>eral<br />
macropinocytosis (TTSS)
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