Shigella Effectors at Work - EMBO

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IpaC-dependent actin nucleation, polymerization, remodeling Wish Wip N Cdc42 Rac Nck ? N-WASP Shigella C B C Grb2 B N Arp2,3 C C Shigella Irsp53 Wave N COOH ? c-Srcc- Src P P P Cortactin Crk PPP PPP Cortactin Cortactin Arp2,3 IpgD IpgD-mediated IpgD mediated release of membrane tension force through PI(4,5)P2 phosphatase activity Bundling of actin filaments (actin ( actin cup) cup and depolymerization (barbed barbed-end end capping) capping) induced by the IpaA-Vinculin IpaA Vinculin complex Shigella Vinculin IpaA Vinculin IpaA Tran Van Nhieu et al., 1998, EMBO J. Bourdet-Sicard et al., 1999, EMBO J. Niebühr Nieb hr et al., 2002, EMBO J. Bougnères Bougn res et al., 2004, J.Cell J. Cell Biol. Biol Ramarao et al., 2007, FEBS Letters Mouunier et al., 2009, PLoS Pathogens
IpaC last 72 aa fused to iota Ia component (Ic ( Ic) ) induce actin-foci actin foci-like like structures Src inhibitor (10 µM) Focal plans, distance in µm from cell basal surface Mounier et al., 2009, PLoS Pathogens
Page 1 and 2: Shigella effectors at work Invasion
Page 3 and 4: HISTOPATHOLOGY OF SHIGELLOSIS ELEME
Page 5 and 6: The Shigella invasion pathogenicity
Page 7 and 8: Posters of the III rd type: Marlise
Page 9 and 10: A. Zipper mechanism Invasin Yersini
Page 11: Alto et al. Ohya et al. IpgB ELMO/D
Page 15 and 16: Rupture, invasion and inflammatory
Page 17 and 18: Adaptation of Shigella to the gut e
Page 19 and 20: GlcNAc O O CH O HCCH 3 CO CO CH 3 L
Page 21 and 22: cytokines chemokines Inhibition of
Page 23 and 24: 37°C Contact virF virB ipaC ipaB i

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