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Alto et al.<br />
Ohya et al.<br />
IpgB<br />
ELMO/Dock<br />
GEF<br />
Wish<br />
Wip<br />
C<br />
Cdc42 Rac<br />
Nck<br />
?<br />
N-WASP<br />
<strong>Shigella</strong><br />
B<br />
Grb2<br />
B<br />
C N N C<br />
GEF<br />
Arp2,3<br />
C<br />
<strong>Shigella</strong><br />
Irsp53<br />
Wave<br />
Actin co<strong>at</strong>, co<strong>at</strong>,<br />
pseudoadherence plaque<br />
inefficient <strong>at</strong> proceeding to internaliz<strong>at</strong>ion<br />
N<br />
VirA<br />
Microtubules<br />
Sasakawa et al.<br />
Hydrophobic domains Coiled-coil Coiled coil domain<br />
IpaC-dependent Actin<br />
nucle<strong>at</strong>ion<br />
polymeriz<strong>at</strong>ion<br />
remodeling<br />
LOADING OF SWISS 3T3 CELLS<br />
WITH IpaC AND anti-IpaC mAbs<br />
Tran Van Nhieu et al., <strong>EMBO</strong> J. 1998<br />
COOH
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