Prions: Protein Aggregation and Infectious Diseases - Physiological ...
Prions: Protein Aggregation and Infectious Diseases - Physiological ...
Prions: Protein Aggregation and Infectious Diseases - Physiological ...
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1140 ADRIANO AGUZZI AND ANNA MARIA CALELLA<br />
on the quality of the tools <strong>and</strong> technologies available to<br />
the prion field. These unresolved questions provide an<br />
opportunity for additional research which may have a<br />
significant impact on further protein misfolding disorders.<br />
ACKNOWLEDGMENTS<br />
This article honors the present <strong>and</strong> past members of the<br />
Aguzzi laboratory, whose enthusiastic commitment led to much<br />
of the work described here. Special thanks to Petra Schwarz for<br />
maintaining our prion-infected mouse colony in impeccable<br />
shape <strong>and</strong> to Rita Moos for excellent technical assistance.<br />
Mathias Heikenwälder, Christina Sigurdson, Jeppe Falsig, <strong>and</strong><br />
Mario Nuvolone provided crucial help with the section on “Immunological<br />
aspects of Prion disease” <strong>and</strong> Simone Hornemann<br />
with the section on “Structures of purified PrP C <strong>and</strong> PrP Sc .”<br />
Certain parts of the history of prion research were adapted from<br />
a previously published book chapter [A. Aguzzi. In: Topley &<br />
Wilson’s Microbiology <strong>and</strong> Microbial Infections (10 th ed.), 2005]<br />
whose previous edition had been published by Dr. Stanley B.<br />
Prusiner. We are grateful to Dr. Prusiner for giving us permission<br />
to utilize some of his material.<br />
Address for reprint requests <strong>and</strong> other correspondence: A.<br />
Aguzzi, Institute of Neuropathology, University Hospital Zürich,<br />
Schmelzbergstrasse 12, CH-8091 Zürich, Switzerl<strong>and</strong> (e-mail:<br />
adriano.aguzzi@usz.ch).<br />
GRANTS<br />
A. Aguzzi is supported by grants from the University of Zurich;<br />
the Swiss Federal Offices of Education, Science, <strong>and</strong> Health; the<br />
Swiss National Foundation; the National Center for Competence in<br />
Research on neural plasticity <strong>and</strong> repair; the United Kingdom Department<br />
for Environment, Food, <strong>and</strong> Rural Affairs; <strong>and</strong> the<br />
Stammbach Foundation. A. M. Calella was supported by the Roche<br />
Research Foundation <strong>and</strong> an EMBO fellowship.<br />
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