Insect Immunity & Drosophila Gut Immune Response

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EC PM B Crop midgut cardia DAPI Pe rfp Hml-gal4, UAS-GFP Malpighian tubules rectum Humans Drosophila Physical barriers Mucus Peritrophic matrix Chemicals, enzymatic barriers Low pH, proteases, lysozymes Flora Complex (>500 sp) Dense (10 12 /ml) Immune Defense AMPs, GALT, M cells Simple (30sp) Rare ROS, AMPs, Gut-associated Hemocytes
Esg‐GFP :  Stem cells,  enteroblasts  newly  generated  enterocytes  Micchelli et al.2006  Mosaic  analysis  lacZ+ clones  Harrison and Perrimon 1993  Unchallenged  Oral infec/on with Ecc15 
Page 1 and 2: Bruno Lemaitre Global Health Instit
Page 3 and 4: The enemies of insects • Viruses:
Page 5 and 6: Bacillus thuringiensis - Gram-posit
Page 8: Plasmodium development in Anopheles
Page 11 and 12: A wasp parasitizing of Drosophila l
Page 13 and 14: Drosophila antiviral defense 1) RNA
Page 15 and 16: Physical and chemical barriers Chit
Page 17 and 18: Cellular immunity Cell type plasmat
Page 19: Activation of melanization Melaniza
Page 23 and 24: The Gut - Site of digestion - Major
Page 25 and 26: Wild-type E. coli DAP-PGN LYS- PGN
Page 27 and 28: PGRP-LB Western Blot (gut extracts)
Page 29 and 30: The Imd pathway is activated throug
Page 31 and 32: Tolerance to gut indigenous flora
Page 33 and 34: Major Remodeling of the Gut upon gu
Page 35 and 36: Mitosis marker staining : phospho h
Page 37 and 38: Epithelium stress & damage Bacteria
Page 39 and 40: WT JAK-STAT deficient Unchallenged
Page 41 and 42: Intestinal muscles Intestinal epith
Page 43 and 44: Pe-GFP Control P. entomophila
Page 45 and 46: Two important host defense mechanis
Page 47 and 48: Collaborators GHI, EPFL, Lausan
Page 49 and 50: Imd deficient flies have a higher b
Page 51: The EGFR pathway coordinates Drosop

Insect Immunity & Drosophila Gut Immune Response

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