Insect Immunity & Drosophila Gut Immune Response

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A Bacterial Effector Targets Mad2L2, an APC Inhibitor, to Modulate Host Cell Cycling Hiroki Iwai et al. 2007 Cell, Vol 130, 611-623, 2007 Summary …Here, we show that the Shigella effector IpaB, when delivered into epithelial cells, causes cellcycle arrest by targeting Mad2L2, an anaphasepromoting complex/cyclosome (APC) inhibitor. .. These results strongly indicate that Shigella employ special tactics to influence epithelial renewal in order to promote bacterial colonization of intestinal epithelium microvilli Tight Jonction crypt α-defensin Paneth Cells Lymphocyte intra-épithélial Stem Cell Richard Locksley et al, <strong>Immunity</strong>.1er édition, p57.)
Collaborators GHI, EPFL, Lausanne (CH)  Nicolas Buchon  Nichole Broderick  Takayuki Kuraishi  Onya Opota  David Welchman  Claudine Neyen  Sveta Chakrabar/  Mathilde Gendrin  Jeremy Herren  Olivier Binggeli  Jean Philippe Boquete  Allison Bardin (Ins/tut Pasteur, France)  Dominique Mengin‐Lecreulx (Orsay, France)  Sylvain Praverdan (CIG, Lausanne)  CGM, Gif‐sur‐Yveae (F)  Anna Zaidman‐Rémy  Mickael Poidevin 
Page 1 and 2: Bruno Lemaitre Global Health Instit
Page 3 and 4: The enemies of insects • Viruses:
Page 5 and 6: Bacillus thuringiensis - Gram-posit
Page 8: Plasmodium development in Anopheles
Page 11 and 12: A wasp parasitizing of Drosophila l
Page 13 and 14: Drosophila antiviral defense 1) RNA
Page 15 and 16: Physical and chemical barriers Chit
Page 17 and 18: Cellular immunity Cell type plasmat
Page 19: Activation of melanization Melaniza
Page 23 and 24: The Gut - Site of digestion - Major
Page 25 and 26: Wild-type E. coli DAP-PGN LYS- PGN
Page 27 and 28: PGRP-LB Western Blot (gut extracts)
Page 29 and 30: The Imd pathway is activated throug
Page 31 and 32: Tolerance to gut indigenous flora
Page 33 and 34: Major Remodeling of the Gut upon gu
Page 35 and 36: Mitosis marker staining : phospho h
Page 37 and 38: Epithelium stress & damage Bacteria
Page 39 and 40: WT JAK-STAT deficient Unchallenged
Page 41 and 42: Intestinal muscles Intestinal epith
Page 43 and 44: Pe-GFP Control P. entomophila
Page 45: Two important host defense mechanis
Page 49 and 50: Imd deficient flies have a higher b
Page 51 and 52: The EGFR pathway coordinates Drosop
Page 53: Esg‐GFP :  Stem cells,  e

Insect Immunity & Drosophila Gut Immune Response

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