Insect Immunity & Drosophila Gut Immune Response
Insect Immunity & Drosophila Gut Immune Response
Insect Immunity & Drosophila Gut Immune Response
Create successful ePaper yourself
Turn your PDF publications into a flip-book with our unique Google optimized e-Paper software.
A Bacterial Effector Targets Mad2L2, an APC<br />
Inhibitor, to Modulate Host Cell Cycling<br />
Hiroki Iwai et al. 2007 Cell, Vol 130, 611-623, 2007<br />
Summary<br />
…Here, we show that the Shigella effector IpaB,<br />
when delivered into epithelial cells, causes cellcycle<br />
arrest by targeting Mad2L2, an anaphasepromoting<br />
complex/cyclosome (APC) inhibitor. ..<br />
These results strongly indicate that Shigella<br />
employ special tactics to influence epithelial<br />
renewal in order to promote bacterial<br />
colonization of intestinal epithelium<br />
microvilli<br />
Tight Jonction<br />
crypt<br />
α-defensin<br />
Paneth Cells<br />
Lymphocyte<br />
intra-épithélial<br />
Stem Cell<br />
Richard Locksley et al, <strong>Immunity</strong>.1er édition, p57.)
Change language