Insect Immunity & Drosophila Gut Immune Response

Two important host defense mechanisms:
- ROS production by DUOX
- Antimicrobial peptide production by the Imd pathway
Negative feedback on the Imd pathway and compartimentation of Imd
pathway activation are important for tolerance and the establishment of
a beneficial flora
A successful response to infection requires coordination of BOTH immune
and homeostatic (repair) pathways
Commensal bacteria stimulate epithelium renewal at a basal level
Epithelium renewal as a target for gut pathogens