Insect Immunity & Drosophila Gut Immune Response
Insect Immunity & Drosophila Gut Immune Response Insect Immunity & Drosophila Gut Immune Response
Control Ecc15 P. entomophila Control P.entomophila Lack of gut integrity death DAPI
Two important host defense mechanisms: - ROS production by DUOX - Antimicrobial peptide production by the Imd pathway Negative feedback on the Imd pathway and compartimentation of Imd pathway activation are important for tolerance and the establishment of a beneficial flora A successful response to infection requires coordination of BOTH immune and homeostatic (repair) pathways Commensal bacteria stimulate epithelium renewal at a basal level Epithelium renewal as a target for gut pathogens
- Page 1 and 2: Bruno Lemaitre Global Health Instit
- Page 3 and 4: The enemies of insects • Viruses:
- Page 5 and 6: Bacillus thuringiensis - Gram-posit
- Page 8: Plasmodium development in Anopheles
- Page 11 and 12: A wasp parasitizing of Drosophila l
- Page 13 and 14: Drosophila antiviral defense 1) RNA
- Page 15 and 16: Physical and chemical barriers Chit
- Page 17 and 18: Cellular immunity Cell type plasmat
- Page 19: Activation of melanization Melaniza
- Page 23 and 24: The Gut - Site of digestion - Major
- Page 25 and 26: Wild-type E. coli DAP-PGN LYS- PGN
- Page 27 and 28: PGRP-LB Western Blot (gut extracts)
- Page 29 and 30: The Imd pathway is activated throug
- Page 31 and 32: Tolerance to gut indigenous flora
- Page 33 and 34: Major Remodeling of the Gut upon gu
- Page 35 and 36: Mitosis marker staining : phospho h
- Page 37 and 38: Epithelium stress & damage Bacteria
- Page 39 and 40: WT JAK-STAT deficient Unchallenged
- Page 41 and 42: Intestinal muscles Intestinal epith
- Page 43: Pe-GFP Control P. entomophila
- Page 47 and 48: Collaborators GHI, EPFL, Lausan
- Page 49 and 50: Imd deficient flies have a higher b
- Page 51 and 52: The EGFR pathway coordinates Drosop
- Page 53: Esg‐GFP : Stem cells, e
Control<br />
Ecc15<br />
P. entomophila<br />
Control<br />
P.entomophila<br />
Lack of gut integrity<br />
death<br />
DAPI
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