Insect Immunity & Drosophila Gut Immune Response
Insect Immunity & Drosophila Gut Immune Response Insect Immunity & Drosophila Gut Immune Response
Duox 1 Imd H2O2 /O ‐ 2 AMPs 1: Recogni/on of bacteria & immune response 2: Bacteria destruc/on & damage to gut cells 3: Cell repair & epithelium renewal What causes damage and epithelium renewal ? What are the pathways ? What is the relevance upon infec/on ? What happens with different types of bacteria ? ? 2 ? ? 3 Buchon et al., 2009, Cell Host & Microbe
Epithelium stress & damage Bacterial direct stress “Collateral damage” Oxidative Stress ???
- Page 1 and 2: Bruno Lemaitre Global Health Instit
- Page 3 and 4: The enemies of insects • Viruses:
- Page 5 and 6: Bacillus thuringiensis - Gram-posit
- Page 8: Plasmodium development in Anopheles
- Page 11 and 12: A wasp parasitizing of Drosophila l
- Page 13 and 14: Drosophila antiviral defense 1) RNA
- Page 15 and 16: Physical and chemical barriers Chit
- Page 17 and 18: Cellular immunity Cell type plasmat
- Page 19: Activation of melanization Melaniza
- Page 23 and 24: The Gut - Site of digestion - Major
- Page 25 and 26: Wild-type E. coli DAP-PGN LYS- PGN
- Page 27 and 28: PGRP-LB Western Blot (gut extracts)
- Page 29 and 30: The Imd pathway is activated throug
- Page 31 and 32: Tolerance to gut indigenous flora
- Page 33 and 34: Major Remodeling of the Gut upon gu
- Page 35: Mitosis marker staining : phospho h
- Page 39 and 40: WT JAK-STAT deficient Unchallenged
- Page 41 and 42: Intestinal muscles Intestinal epith
- Page 43 and 44: Pe-GFP Control P. entomophila
- Page 45 and 46: Two important host defense mechanis
- Page 47 and 48: Collaborators GHI, EPFL, Lausan
- Page 49 and 50: Imd deficient flies have a higher b
- Page 51 and 52: The EGFR pathway coordinates Drosop
- Page 53: Esg‐GFP : Stem cells, e
Epithelium stress & damage<br />
Bacterial direct stress “Collateral damage”<br />
Oxidative<br />
Stress ???
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