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Insect Immunity & Drosophila Gut Immune Response

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The Imd pathway is activated throughout the gut,<br />

BUT<br />

Diptericin shows patterned expression<br />

Diptericin-lacZ<br />

?<br />

PGRP LC<br />

Imd pathway<br />

κB κB κB<br />

Control<br />

Caudal<br />

Diptericin<br />

Caudal RNAi<br />

Ryu et al (2008) Science 319<br />

⇒ additional regulatory elements<br />

restrict Diptericin expression<br />

in some gut cells.

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