Insect Immunity & Drosophila Gut Immune Response

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- A Gram-negative, phytopathogenic bacteria - A natural <strong>Drosophila</strong> pathogen - Induces an Imd-dependent gut immune response upon oral infection Natural infection Filter paper + sucrose  + bacteria Wild-type Wild-type Imd mutant Control Ecc15 Ecc15 Diptericin-lacZ
Wild-type E. coli DAP-PGN LYS- PGN PGRP -LC E12 E. coli Diptericin-lacZ No role for the Toll pathway in the gut Imd Relish κB κB κB DAP PGN AMPs PGRP-LB PGRP-LC
Page 1 and 2: Bruno Lemaitre Global Health Instit
Page 3 and 4: The enemies of insects • Viruses:
Page 5 and 6: Bacillus thuringiensis - Gram-posit
Page 8: Plasmodium development in Anopheles
Page 11 and 12: A wasp parasitizing of Drosophila l
Page 13 and 14: Drosophila antiviral defense 1) RNA
Page 15 and 16: Physical and chemical barriers Chit
Page 17 and 18: Cellular immunity Cell type plasmat
Page 19: Activation of melanization Melaniza
Page 23: The Gut - Site of digestion - Major
Page 27 and 28: PGRP-LB Western Blot (gut extracts)
Page 29 and 30: The Imd pathway is activated throug
Page 31 and 32: Tolerance to gut indigenous flora
Page 33 and 34: Major Remodeling of the Gut upon gu
Page 35 and 36: Mitosis marker staining : phospho h
Page 37 and 38: Epithelium stress & damage Bacteria
Page 39 and 40: WT JAK-STAT deficient Unchallenged
Page 41 and 42: Intestinal muscles Intestinal epith
Page 43 and 44: Pe-GFP Control P. entomophila
Page 45 and 46: Two important host defense mechanis
Page 47 and 48: Collaborators GHI, EPFL, Lausan
Page 49 and 50: Imd deficient flies have a higher b
Page 51 and 52: The EGFR pathway coordinates Drosop
Page 53: Esg‐GFP :  Stem cells,  e

Insect Immunity & Drosophila Gut Immune Response

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