Insect Immunity & Drosophila Gut Immune Response

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The Drosophila immune system: conclusions • Drosophila is now one of the best-characterized host defense systems among the metazoans. • Drosophila has multiple defense “modules” that can be deployed in a coordinated response against distinct pathogens => activation of the appropriate response • There are similarities between Drosophila host defense and essential facets of vertebrate innate immunity (signalling pathways) Future studies should investigate the links between Drosophila immune defense and the ecology of this insect
The Gut - Site of digestion - Major entry site of pathogens - Exposed to commensals (yeast, bacterial flora) Epithelial immunity Innate Immunity Yersinia (Plague) Rickettsia (Typhus) Plasmodium (Malaria) Bacterial tolerance
Page 1 and 2: Bruno Lemaitre Global Health Instit
Page 3 and 4: The enemies of insects • Viruses:
Page 5 and 6: Bacillus thuringiensis - Gram-posit
Page 8: Plasmodium development in Anopheles
Page 11 and 12: A wasp parasitizing of Drosophila l
Page 13 and 14: Drosophila antiviral defense 1) RNA
Page 15 and 16: Physical and chemical barriers Chit
Page 17 and 18: Cellular immunity Cell type plasmat
Page 19: Activation of melanization Melaniza
Page 25 and 26: Wild-type E. coli DAP-PGN LYS- PGN
Page 27 and 28: PGRP-LB Western Blot (gut extracts)
Page 29 and 30: The Imd pathway is activated throug
Page 31 and 32: Tolerance to gut indigenous flora
Page 33 and 34: Major Remodeling of the Gut upon gu
Page 35 and 36: Mitosis marker staining : phospho h
Page 37 and 38: Epithelium stress & damage Bacteria
Page 39 and 40: WT JAK-STAT deficient Unchallenged
Page 41 and 42: Intestinal muscles Intestinal epith
Page 43 and 44: Pe-GFP Control P. entomophila
Page 45 and 46: Two important host defense mechanis
Page 47 and 48: Collaborators GHI, EPFL, Lausan
Page 49 and 50: Imd deficient flies have a higher b
Page 51 and 52: The EGFR pathway coordinates Drosop
Page 53: Esg‐GFP :  Stem cells,  e

Insect Immunity & Drosophila Gut Immune Response

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