ECOG E2100 - Cancer Therapy Evaluation Program (CTEP)
ECOG E2100 - Cancer Therapy Evaluation Program (CTEP)
ECOG E2100 - Cancer Therapy Evaluation Program (CTEP)
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evacizumab<br />
Excellent genetic variability in<br />
IMC-1121B<br />
angiogenesis drug targets<br />
VEGF: multiple<br />
established SNPs in<br />
promoter, 55’UTR,<br />
UTR, &<br />
3’UTR UTR<br />
sunitinib<br />
sorafenib<br />
others…<br />
VEGFR VEGFR-2: 2: significant genetic variability<br />
with several frequent NS SNPs<br />
p85<br />
PLC PLCg<br />
Transcription<br />
factor inhibition<br />
ras<br />
GRB2 SOS
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