ECOG E2100 - Cancer Therapy Evaluation Program (CTEP)
ECOG E2100 - Cancer Therapy Evaluation Program (CTEP)
ECOG E2100 - Cancer Therapy Evaluation Program (CTEP)
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Low baseline<br />
VEGF<br />
high baseline<br />
VEGF<br />
“VEGF low” expressers (-2578AA, -1154AA)<br />
Time<br />
Start bev Stop bev<br />
gradual re-institution of<br />
tumor angiogenesis<br />
“VEGF high” expressers (alternate genotypes)<br />
Hypertension<br />
threshold<br />
Start bev Time<br />
Rebound increase<br />
in angiogenesis:<br />
“Kerbel model”<br />
Stop bev<br />
Hypertension<br />
threshold<br />
prolonged<br />
angiogenesis<br />
blockade<br />
?<br />
never<br />
expose to<br />
angiogenesis<br />
tx
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