ECOG E2100 - Cancer Therapy Evaluation Program (CTEP)
ECOG E2100 - Cancer Therapy Evaluation Program (CTEP) ECOG E2100 - Cancer Therapy Evaluation Program (CTEP)
Conclusions • Pharmacogenetics (biomarkers) – Improves therapeutic index – Leads to drug discovery – Benefits patients • Angiogenesis – Hallmark of malignancy – Inhibition effective in multiple tumor types – Therapeutic heterogeneitybiomarkers needed • Early work suggests germline genetic variability might be important • Validation and further understanding of molecular biology essential “Host Hallmark”
Acknowledgements • David Flockhart MD, PhD • Milan Radovich • Bradley Hancock • Jason Robarge • Lang Li, PhD • Faouzi Azzouz, • Suzanne Lemler, RN • Todd Skaar, PhD • Anne Nguyen • Sunil Badve, MD • George Sledge, MD • Kathy Miller, MD • Anna Maria Storniolo, MD • Connie Rufenbarger • “Friends for Life Coalition” Supported by: ASCO Career Development Award, BCRF, GCRC CreFF Award, Catherine Peachey Fund, & IU Simon Cancer Center
- Page 1 and 2: ECOG Pharmacogenomics: Anti-Angioge
- Page 3 and 4: Genetic variability impacts angioge
- Page 5 and 6: Bevacizumab in breast cancer-E2100:
- Page 7 and 8: PFS Proportion 1.0 0.8 0.6 0.4 0.2
- Page 9 and 10: GOOD NEWS=all subgroups gained bene
- Page 11 and 12: Germline genetic variation in tumor
- Page 13 and 14: Candidate SNPs meet fundamental •
- Page 15 and 16: Genetic variability in tumor angiog
- Page 17 and 18: VEGF -2578 AA & -1154 AA genotypes
- Page 19 and 20: Genetic variability of VEGF predict
- Page 21 and 22: VEGF genotypes may be associated wi
- Page 23 and 24: VEGF Promoter & 5’-UTR Re-sequenc
- Page 25: Caucasians African-Americans 76% 70
Conclusions<br />
• Pharmacogenetics (biomarkers)<br />
– Improves therapeutic index<br />
– Leads to drug discovery<br />
– Benefits patients<br />
• Angiogenesis<br />
– Hallmark of malignancy<br />
– Inhibition effective in multiple tumor types<br />
– Therapeutic heterogeneitybiomarkers<br />
needed<br />
• Early work suggests germline genetic<br />
variability might be important<br />
• Validation and further understanding of<br />
molecular biology essential<br />
“Host Hallmark”
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