賴明毅 - 黃慶璨研究室
賴明毅 - 黃慶璨研究室
賴明毅 - 黃慶璨研究室
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工業製程更可大量生產,在藥物開發是一大優勢。若能對其細胞表面結合受器或<br />
蛋白質結構和功能的相關性有更深入的了解,或許可針對 TH1 的發炎反應或 TH2<br />
的過敏反應設計抑制的藥物。此外,不論是癌症治療或延緩器官移植排斥等自體<br />
免疫疾病,未來也可透過這些真菌活性物質來開發藥物,以免疫療法<br />
(immunetherapy)搭配現有的治療方式,解決許多臨床上的難題。<br />
◎ 參考文獻:<br />
1. Prescilla V. Jeurink, Cristina Lull Noguera, Huub F.J. Savelkoul, and Harry J. Wichers<br />
Immunomodulatory capacity of fungal proteins on the cytokine production of human<br />
peripheral blood mononuclear cells. International Immunopharmacology 8:<br />
1124-1133, 2008<br />
2. Mohammad-Fata Moradali, Hossein Mostafavi, Shirin Ghods, Ghorban-Ali<br />
Hedjaroude Immunomodulating and anticancer agents in the realm of macromycetes<br />
fungi (macrofungi). International Immunopharmacology 7: 701-724, 2007<br />
3. Cristina Lull, Harry J. Wichers, and Huub F. J. Savelkoul Anti-inflammatory and<br />
Immunomodulating Properties of Fungal Metabolites. Mediators of Inflammation<br />
(2005): 63-80, 2005<br />
4
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